Results 71 to 80 of about 122,033 (316)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Modelling and dynamic analysis of an integrated hydraulic forest crane-winch system for timber extraction [PDF]

FME Transactions
This paper details the dynamic modelling and analysis of an integrated hydraulic forest crane-winch system used for timber extraction, concentrating on transient behaviour during winch activation from rest.
Loveikin Viacheslav, Romasevych Yuriy, Bakay Borys, Rudko Ihor, Radiak Ivan   +4 more
doaj   +1 more source

Mechanism and Practice of Multifracturing Using Dynamic Loads in a Low-Permeability Coal Reservoir. [PDF]

ACS Omega, 2023
Qi Y, Tian L, Cao Y, Wu J, Zhang J, Cao Y, Cui B.   +6 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Virtual Testing of Composite Structures Made of High Entropy Alloys and Steel

Metals, 2017
High entropy alloys (HEA) are metallic materials obtained from a mixture of at least five atomic-scale chemical elements. They are characterized by high mechanical strength, good thermal stability and hardenability.
Victor Geantă, Tudor Cherecheș, Paul Lixandru, Ionelia Voiculescu, Radu Ștefănoiu, Daniel Dragnea, Teodora Zecheru, Liviu Matache   +7 more
doaj   +1 more source

Could Horse Gait and Induced Pelvic Dynamic Loads in Female Equestrians Be a Risk Factor in Pudendal Neuralgia? [PDF]

Sports (Basel), 2023
Murer S, Polidori G, Beaumont F, Bogard F, Hakim H, Legrand F.   +5 more
europepmc   +1 more source

DYNAMIC LOAD BALANCING FOR CLOUD: A REVIEW

, 2023
Devendra Suthar, Jitendra Singh Chouhan
openalex   +1 more source

Study on dynamic impact factor of girder bridges due to vehicle load model [PDF]

, 2023
Duc Tran-Van, Toan Nguyen-Xuan, Thao Nguyen-Duy, Loan Nguyen-Thi-Kim   +3 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Application of numerical simulation studies to determine dynamic loads acting on the human masticatory system during unilateral chewing of selected foods. [PDF]

Front Bioeng Biotechnol, 2023
Stróżyk P, Bałchanowski J.
europepmc   +1 more source