Results 71 to 80 of about 7,121,089 (359)

Static and Dynamic Thermomechanical Buckling Loads of Functionally Graded Plates. [PDF]

, 2013
In the paper the buckling phenomenon for static and dynamic loading (pulse of finite duration) of FGM plates subjected to simultaneous action of one directional compression and thermal field is presented.
Kowal-Michalska, Katarzyna, Mania, Radosław J.   +1 more
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Time–Frequency Analysis of Railway Bridges Forced and Free Vibrations Identified by Wavelet Transform

Vibration
In this work, a time–frequency analysis of two railway bridges included in the InBridge4EU project database is presented. The study focuses on the identification of modal parameters from free responses after train passages and their comparison with ...
Pedro Galvín, Antonio Romero, Mario Solís, Emma Moliner, María Dolores Martínez-Rodrigo   +4 more
doaj   +1 more source

Dynamically Loading Mobile/Cloud Assemblies [PDF]

, 2017
Distributed applications that span mobile devices, computing clusters, and cloud services, require robust and flexible mechanisms for dynamically loading code. This paper describes lady: a system that augments the .net platform with a highly reliable mechanism for resolving and loading assemblies, and arranges for safe execution of partially trusted ...
Pettersen, Robert, Johansen, Håvard D., Valvåg, Steffen Viken, Johansen, Dag   +3 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Vibroacoustic Analysis of The Hydrocarbon Processing Plant Piping System Operating at Elevated Temperature. [PDF]

, 2016
In this paper it is presented the vibroacoustic analysis of the selected section of the hydrocarbon processing chemical plant piping system operating at elevated temperature and subjected to dynamic load exciting vibration of the structure.
Błaszczyk, Andrzej, Papierski, Adam, Rydlewicz, Maciej, Susik, Mariusz   +3 more
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

UNSTEADY OPERATING MODES OF THE MAIN DRIVE UNIT OF A MACHINE-TOOLS FOR SOLID RAILWAY WHEELS PROCESSING

Nauka ta progres transportu, 2018
Purpose. The paper deals with determining the conditions of the dynamic overload formation for a drive unit in the wheel-processing machine in various unsteady operating modes and suggests ways to reduce it. Methodology.
R. P. Pogrebnyak
doaj   +1 more source