Results 81 to 90 of about 116,588 (305)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Spatial resolution and property contrast in local mechanical mapping of polymer blends using AFM dynamic force spectroscopy [PDF]

, 2019
The spatial resolution and the contrast in mechanical property mapping by atomic force microscopy (AFM)modes based on dynamic force-curve acquisition, HarmoniX™(HMX) and Peak-Force-Tapping-QNM™(PFT-QNM)modes, are discussed in terms of contact radius ...
Nysten, Bernard, Bahrami, Amir, Bailly, Christian   +2 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Experimental Study of the Dynamic Compressive and Tensile Anisotropic Mechanical Properties and Failure Modes of Shale

Sensors
To investigate the dynamic compressive and tensile mechanical properties and failure modes of shale, split Hopkinson pressure bar (SHPB) and high-speed imaging and digital image correlation (DIC) technologies were adopted.
Qian Dong, Hao Tong, Jinshan Sun, Songlin Peng, Jijie Jia   +4 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Research of the Dynamic Mechanical Property of the Crown Gear Coupling

Jixie chuandong, 2016
The full tooth dynamic finite element model of the GIICL9 crown gear coupling is established based on the ANSYS/LS-DYNA.The research results demonstrate that,the impact phenomenon need to be controlled in the start-up process,and the contact stress ...
Li Feng, Lin Luping, Qi Xiaoli, Wang Min, Pan Ziwei, Zhang Xingquan, Tong Jinyu, Feng Jianyou   +7 more
doaj  

Machine Learning Applications in the Mechanical Analysis of Nanomaterials and Nanostructures

Applied Sciences
Machine learning (ML) is increasingly used to address the computational complexity and multiscale nature of mechanical analysis in nanomaterials and nanostructures. Traditional analytical, numerical, and atomistic approaches, such as continuum mechanics,
Mostafa Sadeghian, Arvydas Palevicius, Paulius Griskevicius, Giedrius Janusas   +3 more
doaj   +1 more source

Dynamical properties and mechanisms of metastability: A perspective in neuroscience

Physical Review E
Metastability, characterized by a variability of regimes in time, is a ubiquitous type of neural dynamics. It has been formulated in many different ways in the neuroscience literature, however, which may cause some confusion. In this Perspective, we discuss metastability from the point of view of dynamical systems theory. We extract from the literature
Kalel L. Rossi, Roberto C. Budzinski, Everton S. Medeiros, Bruno R. R. Boaretto, Lyle Muller, Ulrike Feudel   +5 more
openaire   +3 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Application of dynamic mechanical analysis for the study of viscoelastic properties and identification of softwood and hardwood species [PDF]

EPJ Web of Conferences
Based on experimental studies using dynamic mechanical analysis (DMA) methods, the storage modulus E', loss modulus E", and mechanical loss coefficient tan δ were determined.
Tyurin Alexander, Korenkov Viktor, Samodurov Alexander, Yunak Maria, Rodaev Vyacheslav   +4 more
doaj   +1 more source