Results 101 to 110 of about 1,988,539 (271)

Dynamic Modeling of Cost-effectiveness of Rotavirus Vaccination, Kazakhstan

open access: yesEmerging Infectious Diseases, 2014
The government of Kazakhstan, a middle-income country in Central Asia, is considering the introduction of rotavirus vaccination into its national immunization program.
Birgitte Freiesleben de Blasio   +4 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Unified Framework of Mean-Field Formulations for Optimal Multi-period Mean-Variance Portfolio Selection [PDF]

open access: yes, 2013
The classical dynamic programming-based optimal stochastic control methods fail to cope with nonseparable dynamic optimization problems as the principle of optimality no longer applies in such situations.
Cui, Xiangyu, Li, Duan, Li, Xun
core  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Estimation and Control of WRRF Biogas Production

open access: yesEnergies
The development of resource-efficient digital technologies is a critical challenge in the wastewater sector. This industrial case study, conducted in collaboration with the Veas Water Resource Recovery Facility in Norway, focused on creating data pre ...
Tiina M. Komulainen   +2 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Research on Modeling of the Agile Satellite Using a Single Gimbal Magnetically Suspended CMG and the Disturbance Feedforward Compensation for Rotors

open access: yesSensors, 2012
The magnetically suspended Control Moment Gyroscope (CMG) has the advantages of long-life, micro-vibration and being non-lubricating, and is the ideal actuator for agile maneuver satellite attitude control. However, the stability of the rotor in magnetic
Ning Yan, Peiling Cui
doaj   +1 more source

Dynamic modeling under linear-exponential loss [PDF]

open access: yes
We develop a methodology of parametric modeling of time series dynamics when the underlying loss function is linear-exponential (Linex). We propose to directly model the dynamics of the conditional expectation that determines the optimal predictor.
Stanislav Anatolyev
core  

Modeling Dynamic Functional Connectivity with Latent Factor Gaussian Processes [PDF]

open access: yes, 2019
Dynamic functional connectivity, as measured by the time-varying covariance of neurological signals, is believed to play an important role in many aspects of cognition.
Baldi, Pierre   +5 more
core   +1 more source

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