Results 121 to 130 of about 11,891,122 (316)
Effective Connectivity and Bias Entropy Improve Prediction of Dynamical Regime in Automata Networks [PDF]
, 2023 Felipe Xavier Costa +3 more
openalex +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
A Process-Based Approach to Transtheoretical Clinical Research and Training
Clinical Psychology in Europe[Background] The science and practice of psychopathology and psychological intervention of today is more like an island archipelago than it is a single land mass, and connections between different traditions are both limited and fraught with ...
Stefan G. Hofmann, Steven C. Hayes
doaj +1 more source
The maximum flow in dynamic networks [PDF]
Computer Science Journal of Moldova, 2005 The dynamic maximum flow problem that generalizes the static maximum flow problem is formulated and studied. We consider the problem on a network with capacities depending on time, fixed transit times on the arcs, and a given time horizon.
Maria A. Fonoberova, Dmitrii D. Lozovanu
doaj
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Modeling homophily in dynamic networks with application to HIV molecular surveillance. [PDF]
BMC Infect Dis, 2023 DeGruttola V +7 more
europepmc +1 more source
[Retracted] Wireless Network Virtualization Resource Sharing Based on Dynamic Resource Allocation Algorithm [PDF]
, 2022 Jie Ren, Xiaolong Li
openalex +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source