Results 71 to 80 of about 395,732 (262)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Blockchain in Dynamic Networks

, 2022
We consider blockchain in dynamic networks. We define the Blockchain Decision Problem. It requires miners that maintain the blockchain to confirm whether a particular block is accepted. We establish the necessary conditions for the existence of a solution.
Bricker, Rachel, Nesterenko, Mikhail, Sharma, Gokarna   +2 more
openaire   +2 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Origin of Dynamic Network Formation of 2D Nanofillers in a Flexible Matrix

Small Structures
The aggregation of carbon nanofillers within polymer matrices is a crucial phenomenon for the formation of conducting channels in electrically conductive composites.
Debmalya Roy, Vaishnav B, Subhash Mandal, Ajay Gupta, Benedikt Sochor, Sarathlal Koyiloth Vayalil, Tobias Kraus   +6 more
doaj   +1 more source

Towards Secure and Efficient Farming Using Self-Regulating Heterogeneous Federated Learning in Dynamic Network Conditions

Agriculture
The advancement of precision agriculture increasingly depends on innovative technological solutions that optimize resource utilization and minimize environmental impact.
Sai Puppala, Koushik Sinha
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A Process-Based Approach to Transtheoretical Clinical Research and Training

Clinical Psychology in Europe
[Background] The science and practice of psychopathology and psychological intervention of today is more like an island archipelago than it is a single land mass, and connections between different traditions are both limited and fraught with ...
Stefan G. Hofmann, Steven C. Hayes
doaj   +1 more source

An Enhanced Incremental SVD Algorithm for Change Point Detection in Dynamic Networks

IEEE Access, 2018
Change point detection is essential to understand the time-evolving structure of dynamic networks. Recent research shows that a latent semantic indexing (LSI)-based algorithm effectively detects the change points of a dynamic network.
Yongsheng Cheng, Jiang Zhu, Xiaokang Lin
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The maximum flow in dynamic networks [PDF]

Computer Science Journal of Moldova, 2005
The dynamic maximum flow problem that generalizes the static maximum flow problem is formulated and studied. We consider the problem on a network with capacities depending on time, fixed transit times on the arcs, and a given time horizon.
Maria A. Fonoberova, Dmitrii D. Lozovanu
doaj