Results 101 to 110 of about 4,566,403 (297)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Dynamic docking strategies for a bioinspired AUV

Engineering Applications of Computational Fluid Mechanics
AUV docking and recovery pose several challenges operationally. The procedure requires the mothership to stop and remain stationary, an impractical demand in harsh offshore environments; hence a recovery system capable of retrieving an AUV while the ...
Yunxin Xu, Weichao Shi, Yang Song, Laibing Jia   +3 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Autonomous recovery control method for USV based on dynamic programming guidance

Zhongguo Jianchuan Yanjiu
ObjectiveThis paper presents a tracking control method based on dynamic programming guidance to address the challenges presented by the autonomous recovery of underactuated unmanned surface vehicles (USVs). MethodsAt the kinematic level, constant bearing
Wenxuan GUO, Zihao LI, Guoyuan TANG, Quanbin WANG, Jianglong SUN, Jie MA, Yu QIAO   +6 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Information Recovery in a Dynamic Statistical Markov Model

Econometrics, 2015
Although economic processes and systems are in general simple in nature, the underlying dynamics are complicated and seldom understood. Recognizing this, in this paper we use a nonstationary-conditional Markov process model of observed aggregate data to ...
Douglas J. Miller, George Judge
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

High temperature stress-strain data for SAE 5120 steel under various strain ratesDataverse

Data in Brief
SAE 5120 is a low-alloy chromium steel widely used in automotive, aerospace, and construction industries for mechanically loaded components. To preserve its mechanical properties and prevent cracking or poor grain structure, it is typically hot-formed ...
Philippe Moreau, Jean-Dominique Guérin, José Grégorio La Barbara Sosa, Eli Puchi Cabrera, André Dubois, Laurent Dubar   +5 more
doaj   +1 more source

Robust Spectral Recovery for Dynamical Sampling

CoRR
We study the spectral recovery problem for dynamical sampling on a finite cyclic grid. Given time snapshots obtained from a fixed uniform spatial subsampling of the orbit $x_{\ell}=A^{\ell}f$, we aim to recover the spectrum of the unknown circular convolution operator $A$.
HanQin Cai, Longxiu Huang, Tianming Wang, Juntao You   +3 more
openaire   +2 more sources