Results 91 to 100 of about 370,697 (266)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

High temperature stress-strain data for SAE 5120 steel under various strain ratesDataverse

Data in Brief
SAE 5120 is a low-alloy chromium steel widely used in automotive, aerospace, and construction industries for mechanically loaded components. To preserve its mechanical properties and prevent cracking or poor grain structure, it is typically hot-formed ...
Philippe Moreau, Jean-Dominique Guérin, José Grégorio La Barbara Sosa, Eli Puchi Cabrera, André Dubois, Laurent Dubar   +5 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Sequential recovery of power system in cascading failure based on Recovery Probability Matrix

International Journal of Electrical Power & Energy Systems
Cascading failure in power system may trigger extensive blackouts with severe societal consequences. This paper proposes a probabilistic recovery framework that centers on a Recovery Probability Matrix (RPM).
Lei Chen, Sijia Guo, Yijing Lu, Hui Ge, Jianbo Chen, Shengquan Li   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Dynamic Recovery from Depression Enables Rate Encoding in Inhibitory Synapses. [PDF]

iScience, 2020
Bridi MS, Shin S, Huang S, Kirkwood A.
europepmc   +1 more source

The dynamics of bicycles for disaster recovery and relief

Scientific Reports
Micromobility offers a potential pathway to strengthen urban disaster resilience by enabling the distribution of emergency supplies when infrastructure or transportation networks are compromised. This study examines the viability of micromobility vehicles for post-disaster relief via agent-based modeling and simulations in Stillwater, Oklahoma ...
Qiu, Qianli, Chen, Chen, Idziorek, Katherine, Wong, Stephen D.   +3 more
openaire   +2 more sources

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Energy regeneration: A study on dynamic capacitance adjustment technology in piezoelectric shock absorbers for electric vehicles under varied road conditions.

PLoS ONE
This study investigates the performance of dynamic capacitance regulation technology in electric vehicle piezoelectric shock absorbers for energy recovery under varying road conditions.
Shih-Lin Lin
doaj   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source