Results 91 to 100 of about 367,224 (266)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Strengthening nanostructured metals through dynamic recovery

Journal of Materials Research and Technology
Recovery plays distinct roles in nanostructured and coarse-grained metallic materials. While static and dynamic recovery usually soften work-hardened, coarse-grained materials, static recovery has been shown to strengthen nanostructured metals.
Amanda P. Carvalho, Aoyan Liang, Megumi Kawasaki, Livia Cupertino-Malheiros, Paulo S. Branicio, Roberto B. Figueiredo   +5 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Analytical Descriptions of Dynamic Softening Mechanisms for Ti-13Nb-13Zr Biomedical Alloy in Single Phase and Two Phase Regions

Archives of Metallurgy and Materials, 2017
Dynamic softening behaviors of a promising biomedical Ti-13Nb-13Zr alloy under hot deformation conditions across dual phase α + β and single phase β regions were quantitatively characterized by establishing corresponding dynamic recovery (DRV) and ...
Quan G.-Z., Wang X., Li Y.-L., Zhang L.
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Dynamic docking strategies for a bioinspired AUV

Engineering Applications of Computational Fluid Mechanics
AUV docking and recovery pose several challenges operationally. The procedure requires the mothership to stop and remain stationary, an impractical demand in harsh offshore environments; hence a recovery system capable of retrieving an AUV while the ...
Yunxin Xu, Weichao Shi, Yang Song, Laibing Jia   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Autonomous recovery control method for USV based on dynamic programming guidance

Zhongguo Jianchuan Yanjiu
ObjectiveThis paper presents a tracking control method based on dynamic programming guidance to address the challenges presented by the autonomous recovery of underactuated unmanned surface vehicles (USVs). MethodsAt the kinematic level, constant bearing
Wenxuan GUO, Zihao LI, Guoyuan TANG, Quanbin WANG, Jianglong SUN, Jie MA, Yu QIAO   +6 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source