Results 71 to 80 of about 367,224 (266)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

STATE VECTOR RECOVERY FOR NONLINEAR DYNAMIC SYSTEMS

Міжнародний науково-технічний журнал "Проблеми керування та інформатики", 2007
As it is shown in the paper, state vector recovery necessarily requires the robust stability of an extended system. This can be achieved by choosing the respective control law of a recovery system. The robust stability sufficient conditions for a domain,
V.M. Kuntsevich
doaj   +1 more source

Dynamic Matrix Recovery

Journal of the American Statistical Association
Journal of the American Statistical Association (2023)
Ziyuan Chen, Ying Yang, Fang Yao
openaire   +2 more sources

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Dynamic recrystallization behavior and transformation mechanism in β-phase region of TB17 titanium alloy

Cailiao gongcheng, 2019
The thermal compression experiment of TB17 titanium alloy in the β phase region was carried out by Gleeble-3800 hot compression simulator. The dynamic recrystallization behavior and transformation mechanism in the β phase region of the TB17 titanium ...
ZHU Hong-chang, LUO Jun-ming, ZHU Zhi-shou   +2 more
doaj  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

DYNAMICAL RECOVERY AND DIFFUSION

Le Journal de Physique Colloques, 1979
Plastic deformation techniques can be applied to investigate self-diffusion in Si and Ge. By this way, activation energies of 2.8 eV and 3.6 eV for Ge and Si, respectively, were deduced. For Si, the pre-exponential factor Do was estimated to be 0.5 cm2/s. These results are discussed in terms of diffusion by a monovacancy mechanism.
openaire   +2 more sources

Dynamic VAR planning methodology to enhance transient voltage stability for failure recovery

Journal of Modern Power Systems and Clean Energy, 2017
In recent years, failure recovery after faults is concerned and discussed worldwide as an important and hot topic. Facing the challenge of heavy loads and ultra-high voltage transmission, it’s urgent to propose some solutions to enhance transient voltage
Di YANG, Haozhong CHENG, Zeliang MA, Liangzhong YAO, Zhonglie ZHU   +4 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source