Results 71 to 80 of about 1,338,644 (306)
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Environmental Research Letters, 2022 Optimizing the allocation schemes of post-disaster recovery resources can promote the sustainable development of a regional economy. However, previous studies determined the inputs and allocation schemes of recovery resources based on direct economic (DE)
Hongwei Li +3 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Computational Analysis of Self-Healing in Nanomaterials Using Neural Spike Algorithms
InformationThis computational study investigates dynamic self-healing processes in nanomaterials driven by neuronal spike activity. We developed a multiscale simulation framework that integrates neuronal dynamics, quantum mechanical effects, and material science ...
Jongho Seol +2 more
doaj +1 more source
Strategies to augment volitional and reflex function may improve locomotor capacity following incomplete spinal cord injury [PDF]
, 2018 Many studies highlight the remarkable plasticity demonstrated by spinal circuits following an incomplete spinal cord injury (SCI). Such plasticity can contribute to improvements in volitional motor recovery, such as walking function, although similar ...
Hornby, T. George +2 more
core +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Cailiao gongcheng, 2020 The thermal compression experiment of TB17 titanium alloy in the β phase region was carried out by Gleeble-3800 hot compression simulator. The dynamic recrystallization behavior and transformation mechanism in the β phase region of the TB17 titanium ...
ZHU Hong-chang +2 more
doaj
A Dynamic Game Analysis and Design of Infrastructure Network Protection and Recovery
, 2017 Infrastructure networks are vulnerable to both cyber and physical attacks. Building a secure and resilient networked system is essential for providing reliable and dependable services.
Chen, Juntao +2 more
core +3 more sources
A constraint–relaxation–recovery mechanism for stomatal dynamics [PDF]
Plant, Cell & Environment, 2019 AbstractModels of guard cell dynamics, built on the OnGuard platform, have provided quantitative insights into stomatal function, demonstrating substantial predictive power. However, the kinetics of stomatal opening predicted by OnGuard models were threefold to fivefold slower than observed in vivo.
Mareike Jezek +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source