Results 81 to 90 of about 4,566,403 (297)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
A Nonconvex Framework for Structured Dynamic Covariance Recovery
CoRR, 2020 We propose a flexible yet interpretable model for high-dimensional data with time-varying second order statistics, motivated and applied to functional neuroimaging data. Motivated by the neuroscience literature, we factorize the covariances into sparse spatial and smooth temporal components. While this factorization results in both parsimony and domain
Katherine Tsai +2 more
openaire +5 more sources
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Dynamic VAR planning methodology to enhance transient voltage stability for failure recovery
Journal of Modern Power Systems and Clean Energy, 2017 In recent years, failure recovery after faults is concerned and discussed worldwide as an important and hot topic. Facing the challenge of heavy loads and ultra-high voltage transmission, it’s urgent to propose some solutions to enhance transient voltage
Di YANG +4 more
doaj +1 more source
Resource Constrained Project Scheduling With Dynamic Disruption Recovery
IEEE Access, 2020 Resource-constrained project scheduling is one of the most widely studied research problems. Although a large number of algorithms have been developed for solving these problems, many of them ignored several practical issues such as resource ...
Forhad Zaman +3 more
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Archives of Metallurgy and Materials, 2017 Dynamic softening behaviors of a promising biomedical Ti-13Nb-13Zr alloy under hot deformation conditions across dual phase α + β and single phase β regions were quantitatively characterized by establishing corresponding dynamic recovery (DRV) and ...
Quan G.-Z., Wang X., Li Y.-L., Zhang L.
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Hot deformation and microstructure evolution of TiZrAlHf Ti-based medium entropy alloy
Cailiao gongchengIn order to optimize the hot working window of the novel TiZrAlHf Ti-based medium entropy alloy, the thermal deformation characteristics and microstructural evolution during thermal deformation were investigated by using hot compression simulation ...
LIU Qianqian +5 more
doaj +1 more source