Results 41 to 50 of about 1,078,035 (244)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Research on Impact Resistance of Steel Frame Beam-Column Structure Under Fire

Buildings
In this study, the impact resistance of WUF-B steel frame beam–column joints under fire was investigated using ABAQUS finite element software through a sequential thermal–mechanical coupling approach. By integrating a room-temperature impact model with a
Zhi Li, Yu-Tong Feng, Tian-Qi Xue
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Challenges in Risk Analysis and Assessment of the Railway Transport Vibration on Buildings

Applied Sciences
Traffic-induced vibrations from road and rail systems pose a significant threat to the structural integrity and operational safety of buildings, especially masonry structures located near planned infrastructure such as tunnels.
Filip Pachla, Tadeusz Tatara, Waseem Aldabbik   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Experimental study on dynamic characteristics and energy dissipation of weakly cemented rock-like materials

Frontiers in Materials
The structural stability of coal seam roof rock mass under dynamic load in engineering practice is directly influenced by the dynamic characteristics of weakly consolidated coal measures rock.
Guodong Shi, Duoxi Yao, Jiehao Wu, Jiehao Wu, Fangyi Meng   +4 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Dynamic Characteristics and Parametric Sensitivity Analysis of Underground Powerhouse in Pumped Storage Power Stations

Applied Sciences
China has witnessed extensive construction of underground powerhouses for pumped storage power stations. With the continuous increase in unit capacity, vibration problems have become particularly pronounced.
Junhao Gao, Zhenzhong Shen, Yiqing Sun, Lei Gan, Liqun Xu, Hongwei Zhang, Yaxin Feng, Yong Ni, Yanhe Zhang, Yang Xiang   +9 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Measurement of Dynamic Response and Analysis of Characteristics of Heavy-Haul Railway Tunnel Bottom Structure Under Train Loading

Buildings
This study investigates the dynamic response characteristics of the tunnel bottom structure, focusing on a heavy-haul railway tunnel. To assess the condition of the tunnel bottom, geological radar and drilling core techniques were employed, along with on-
Dengke Wang, Jie Su, Furong Luo, Zhe Wang, Jiansheng Fan, Jianjun Luo, Guanqing Wang   +6 more
doaj   +1 more source