Results 91 to 100 of about 3,118,026 (239)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Macro-routing: a new hierarchical routing protocol [PDF]

open access: yes, 2004
In a continually evolving Internet, tools such as quality of service routing must be used in order to accommodate user demands. QoS routing raises scalability issues within very large networks, which can he avoided by using hierarchical routing ...
Martin Collier   +5 more
core   +2 more sources

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

Current State of Dynamic Vehicle Routing Problems Solved by Ant Colony Optimization Algorithm

open access: yesTehnički Glasnik, 2021
Dynamic Vehicle Routing Problem is a more complex version of Vehicle Routing Problem, closer to the present, real-world problems. Heuristic methods are used to solve the problem as Vehicle Routing Problem is NP-hard. Among many different solution methods,
Luka Olivari, Goran Đukić
doaj  

A Numerical–Experimental Approach for Multi‐Matrix Fiber‐Reinforced Plastics Characterization Using Finite Element Model Updating

open access: yesAdvanced Engineering Materials, EarlyView.
A numerical–experimental framework is developed for characterizing multi‐matrix fiber‐reinforced polymers (MM‐FRPs) combining epoxy and polyurethane matrices. Harmonic bending tests are integrated with finite element model updating (FEMU) to simultaneously identify elastic and viscoelastic material parameters.
Rodrigo M. Dartora   +4 more
wiley   +1 more source

Interdomain routing and games [PDF]

open access: yes
We present a game-theoretic model that captures many of the intricacies of \emph{interdomain routing} in today's Internet. In this model, the strategic agents are source nodes located on a network, who aim to send traffic to a unique destination node ...
Zohar, Aviv   +2 more
core  

Multi-Path Transmission Protocol for Video Streaming Over Vehicular Fog Computing Environments

open access: yesIEEE Access
Delivering real-time multimedia content for safety applications over vehicular networks presents significant challenges due to rapidly changing network topology, high node mobility, and fluctuating traffic demands, compounded by substantial data volumes ...
Sarra Benzerogue   +4 more
doaj   +1 more source

Towards Defect Phase Diagrams: From Research Data Management to Automated Workflows

open access: yesAdvanced Engineering Materials, EarlyView.
A research data management infrastructure is presented for the systematic integration of heterogeneous experimental and simulation data required for defect phase diagrams. The approach combines openBIS with a companion application for large‐object storage, automated metadata extraction, provenance tracking and federated data access, thereby supporting ...
Khalil Rejiba   +5 more
wiley   +1 more source

Waiting Strategy for the Dynamic Meal Delivery Routing Problem with Time-Sensitive Customers Using a Hybrid Adaptive Genetic Algorithm and Adaptive Large Neighborhood Search Algorithm

open access: yesSystems
In this paper, we study the dynamic meal delivery routing problem (MDRP) with time-sensitive customers. The multi-objective MDRP optimization model is developed to maximize customer satisfaction and minimize delay penalty cost and riding cost.
Wenjie Wang, Shen Gao
doaj   +1 more source

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