Results 71 to 80 of about 37,081 (313)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Connectivity aware routing - a method for finding bandwidth constrained paths over a variety of network topologies [PDF]
, 2003 Multimedia traffic and real-time e-commerce applications can experience quality degradation in traditional networks such as the Internet. These difficulties can be overcome in networks which feature dynamically set up paths with bandwidth and delay ...
M. Collier +3 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Journal of Telecommunications and Information Technology, 2003 The paper describes new developments of a multiple objective dynamic routing method (MODR) for circuit-switched networks previously presented, based on the periodic calculation of alternative paths for every node pair by a specialised bi-objective ...
Lúcia Martins
doaj +1 more source
Disruption management of the vehicle routing problem with vehicle breakdown [PDF]
, 2011 This paper introduces a new class of problem, the disrupted vehicle routing problem (VRP), which deals with the disruptions that occur at the execution stage of a VRP plan.
Eglese, R W, Mu, Q, Fu, Z, Lysgaard, J
core
Pervasive intelligent routing in content centric delay tolerant networks [PDF]
, 2011 This paper introduces a Swarm-Intelligence based Routing protocol (SIR) that aims to efficiently route information in content centric Delay Tolerant Networks (CCDTN) also dubbed pocket switched networks.
Ramiro, Victor +7 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
The two-echelon capacitated vehicle routing problem: models and math-based heuristics [PDF]
, 2011 Multiechelon distribution systems are quite common in supply-chain and logistics. They are used by public administrations in their transportation and traffic planning strategies, as well as by companies, to model own distribution systems.
R. Tadei +9 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Improved learning automata applied to routing in multi-service networks [PDF]
, 2000 Multi-service communications networks are generally designed, provisioned and configured, based on source-destination user demands expected to occur over a recurring time period.
Aranzulla, P.J., Aranzulla, Philip John
core