Results 71 to 80 of about 61,879 (313)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A genetic algorithm for dynamic scheduling in emergency departments with priorities [PDF]

, 2011
A hospital is a very complex environment and its management is a hard task. The point we explore in this thesis is the management of the patient flow for the Emergency Department. The main contribution of the thesis is twofold: on the one hand, we design
Bergamin, Filippo
core  

Application of simulated annealing algorithm in multi-objective cooperative scheduling of load and storage of source network for load side of new power system

Energy Informatics
To improve the adaptability of grid load collaborative scheduling, a multi-objective collaborative scheduling method based on a simulated annealing algorithm for the load storage of grid loads on the load side of a new power system is proposed. Local bus
Xinming Wang, Huayang Liang, Xiaobo Jia, Shihui Li, Shengyang Kang, Yan Gao   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Application of velocity-based gain-scheduling to lateral auto-pilot design for an agile missile [PDF]

, 2001
In this paper a modern gain-scheduling methodology is proposed which exploits recently developed velocity-based techniques to resolve many of the deficiencies of classical gain-scheduling approaches (restriction to near equilibrium operation, to slow ...
Tsourdos, A., Leithead, W.E., White, B., Leith, D.J.   +3 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Study on the job shop fuzzy dynamic scheduling based on virtual pre-scheduling [PDF]

, 2006
Dynamic Job Shop scheduling is a frequently occurring and highly relevant problem in practical fuzzy manufacture environment. Previous research suggested that periodic rescheduling improves classical measures of efficiency; however, this strategy had the
Zhu YL(朱云龙), Song XY(宋晓宇), Yin CW(尹朝万), Li FM(李富明)   +3 more
core  

Automated generation of dispatching rules for the green unrelated machines scheduling problem

Complex & Intelligent Systems
The concept of green scheduling, which deals with the environmental impact of the scheduling process, is becoming increasingly important due to growing environmental concerns.
Nikolina Frid, Marko Ɖurasević, Francisco Javier Gil-Gala   +2 more
doaj   +1 more source

Dynamic Multi Threshold Priority Packet Scheduling Algorithms

MATEC Web of Conferences, 2016
Packet scheduling algorithms are developed in order to use shared transmission resources efficiently. Various application packets such as real and non-real time packets might have different QoS requirements and traditional scheduling algorithms might be ...
Dag Tamer, Uzungenc Sezer
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source