Results 41 to 50 of about 312,196 (245)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Numerical Investigation of Flow Field Characteristics around Two Ship Hull Sections with Different Reynolds Numbers

Journal of Marine Science and Engineering
In the field of ocean engineering, the variation of flow field during ship-to-ship (STS) interaction has been a hot topic. Noteworthy, the effect of vortex distribution on flow field characteristic variations during STS interaction remains insufficiently
Jiaqi Zhou, Junsheng Ren, Can Tu, Shixue Yang   +3 more
doaj   +1 more source

Development of a Multi-Directional Manoeuvre for Unified Handling Qualities Investigation

Aerospace, 2019
A slalom and alignment tracking manoeuvre was developed for multi-directional handling qualities analysis of large transport aircraft in simulation environments.
Gaétan Dussart, Mudassir Lone, Roger Bailey   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Muscle prestimulation tunes velocity preflex in simulated perturbed hopping

Scientific Reports, 2023
Muscle fibres possess unique visco-elastic properties, which generate a stabilising zero-delay response to unexpected perturbations. This instantaneous response—termed “preflex”—mitigates neuro-transmission delays, which are hazardous during fast ...
Fabio Izzi, An Mo, Syn Schmitt, Alexander Badri-Spröwitz, Daniel F. B. Haeufle   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Ship Anomalous Behavior Detection Using Clustering and Deep Recurrent Neural Network

Journal of Marine Science and Engineering, 2023
In this study, we propose a real-time ship anomaly detection method driven by Automatic Identification System (AIS) data. The method uses ship trajectory clustering classes as a normal model and a deep learning algorithm as an anomaly detection tool. The
Bohan Zhang, Katsutoshi Hirayama, Hongxiang Ren, Delong Wang, Haijiang Li   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Muscle preflex response to perturbations in locomotion: In vitro experiments and simulations with realistic boundary conditions

Frontiers in Bioengineering and Biotechnology, 2023
Neuromuscular control loops feature substantial communication delays, but mammals run robustly even in the most adverse conditions. In vivo experiments and computer simulation results suggest that muscles’ preflex—an immediate mechanical response to a ...
Matthew Araz, Matthew Araz, Sven Weidner, Fabio Izzi, Fabio Izzi, Alexander Badri-Spröwitz, Alexander Badri-Spröwitz, Tobias Siebert, Daniel F. B. Haeufle, Daniel F. B. Haeufle, Daniel F. B. Haeufle   +10 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source