Results 51 to 60 of about 1,818,666 (298)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Startup of a reactive distillation process with a decanter [PDF]

, 2008
The startup of a reactive distillation process for the production of propyl acetate including a decanter is studied. A simulation model is presented which describes the whole startup from a cold and empty state and takes into account the liquid phase ...
Brehelin, Mathias, Forner, Florian, Meyer, Michel, Repke, Jens Uwe, Rouzineau, David   +4 more
core   +3 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Numerical Investigation of Flow Field Characteristics around Two Ship Hull Sections with Different Reynolds Numbers

Journal of Marine Science and Engineering
In the field of ocean engineering, the variation of flow field during ship-to-ship (STS) interaction has been a hot topic. Noteworthy, the effect of vortex distribution on flow field characteristic variations during STS interaction remains insufficiently
Jiaqi Zhou, Junsheng Ren, Can Tu, Shixue Yang   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Development of a Multi-Directional Manoeuvre for Unified Handling Qualities Investigation

Aerospace, 2019
A slalom and alignment tracking manoeuvre was developed for multi-directional handling qualities analysis of large transport aircraft in simulation environments.
Gaétan Dussart, Mudassir Lone, Roger Bailey   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Muscle prestimulation tunes velocity preflex in simulated perturbed hopping

Scientific Reports, 2023
Muscle fibres possess unique visco-elastic properties, which generate a stabilising zero-delay response to unexpected perturbations. This instantaneous response—termed “preflex”—mitigates neuro-transmission delays, which are hazardous during fast ...
Fabio Izzi, An Mo, Syn Schmitt, Alexander Badri-Spröwitz, Daniel F. B. Haeufle   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Ship Anomalous Behavior Detection Using Clustering and Deep Recurrent Neural Network

Journal of Marine Science and Engineering, 2023
In this study, we propose a real-time ship anomaly detection method driven by Automatic Identification System (AIS) data. The method uses ship trajectory clustering classes as a normal model and a deep learning algorithm as an anomaly detection tool. The
Bohan Zhang, Katsutoshi Hirayama, Hongxiang Ren, Delong Wang, Haijiang Li   +4 more
doaj   +1 more source