Results 61 to 70 of about 5,828,755 (297)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Integration of an object formalism within a hybrid dynamic simulation environment [PDF]

, 2004
PrODHyS is a general object-oriented environment which provides common and reusable components designed for the development and the management of dynamic simulation of systems engineering.
Le Lann, Jean-Marc, Hétreux, Gilles, Perret, Jocelyne   +2 more
core   +1 more source

Muscle prestimulation tunes velocity preflex in simulated perturbed hopping

Scientific Reports, 2023
Muscle fibres possess unique visco-elastic properties, which generate a stabilising zero-delay response to unexpected perturbations. This instantaneous response—termed “preflex”—mitigates neuro-transmission delays, which are hazardous during fast ...
Fabio Izzi, An Mo, Syn Schmitt, Alexander Badri-Spröwitz, Daniel F. B. Haeufle   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Ship Anomalous Behavior Detection Using Clustering and Deep Recurrent Neural Network

Journal of Marine Science and Engineering, 2023
In this study, we propose a real-time ship anomaly detection method driven by Automatic Identification System (AIS) data. The method uses ship trajectory clustering classes as a normal model and a deep learning algorithm as an anomaly detection tool. The
Bohan Zhang, Katsutoshi Hirayama, Hongxiang Ren, Delong Wang, Haijiang Li   +4 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Muscle preflex response to perturbations in locomotion: In vitro experiments and simulations with realistic boundary conditions

Frontiers in Bioengineering and Biotechnology, 2023
Neuromuscular control loops feature substantial communication delays, but mammals run robustly even in the most adverse conditions. In vivo experiments and computer simulation results suggest that muscles’ preflex—an immediate mechanical response to a ...
Matthew Araz, Matthew Araz, Sven Weidner, Fabio Izzi, Fabio Izzi, Alexander Badri-Spröwitz, Alexander Badri-Spröwitz, Tobias Siebert, Daniel F. B. Haeufle, Daniel F. B. Haeufle, Daniel F. B. Haeufle   +10 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

06161 Abstracts Collection – Simulation and Verification of Dynamic Systems [PDF]

, 2006
From 17.04.06 to 22.04.06, the Dagstuhl Seminar 06161 ``Simulation and Verification of Dynamic Systems'' was held in the International Conference and Research Center (IBFI), Schloss Dagstuhl.
Priami, Corrado, Riis-Nielson, Hanne, Uhrmacher, Adelinde M., Nicol, David M.   +3 more
core   +1 more source

Large eddy simulation of buoyant plumes [PDF]

, 2003
A 3d parallel CFD code is written to investigate the characteristics of and differences between Large Eddy Simulation (LES) models in the context of simulating a thermal buoyant plume. An efficient multigrid scheme is incorporated to solve the Poisson
Worthy, Jude
core   +5 more sources