Results 61 to 70 of about 326,621 (219)

The effects of numerical acceleration techniques on PIC-MCC simulations of ion thrusters

open access: yesAIP Advances, 2020
The particle-in-cell-Monte Carlo collision method has been widely used in simulation studies of ion thrusters. Due to the huge computational demand of such simulations, numerical acceleration techniques are required.
Tiannan Yuan   +5 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Shear failure mechanisms and influences of overlaminate configuration on the failure of composite π joints

open access: yesResults in Physics, 2019
All-composite adhesively bonded π-shaped joints, designed for integrated composite structures, have attracted increasing attention on account of their excellent mechanical behaviors.
Kangkang Wang, Fengrui Liu, Haiming Hong
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

Research on shore-based intelligent vessel support system based on multi-source navigation sensors simulation

open access: yesInternational Journal of Distributed Sensor Networks, 2019
Under the guidance of industry 4.0, peoples pay more attention to the intelligent equipment and system. Intelligent vessel without crew on board has acquired growing attention worldwide over the years.
Xiao Yang, Jing-jing Lian, Hongxiang Ren
doaj   +1 more source

Dynamic Simulation of Heat Transfer through External Building Constructions

open access: yesЖурнал інженерних наук, 2019
In the paper, some approaches to dynamic modeling of heat transfer through external building constructions are presented. The model of heat transfer dynamics through a wall was designed on the base of mathematical describing of an energy balance for the ...
Pitel J.   +3 more
doaj   +1 more source

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