Results 71 to 80 of about 1,818,666 (298)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Bi-Level Optimization in a Transport Network

Cybernetics and Information Technologies, 2015
This paper applies a bi-level formalism for the optimal control of an urban transportation network. The well known store-and-forward model in traffic control is utilized in order to increase the control space of the optimization problem.
Stoilov Todor, Stoilova Krasimira, Papageorgiou Markos, Papamichail Ioannis   +3 more
doaj   +1 more source

Decision-Making for the Autonomous Navigation of Maritime Autonomous Surface Ships Based on Scene Division and Deep Reinforcement Learning

Sensors, 2019
This research focuses on the adaptive navigation of maritime autonomous surface ships (MASSs) in an uncertain environment. To achieve intelligent obstacle avoidance of MASSs in a port, an autonomous navigation decision-making model based on hierarchical ...
Xinyu Zhang, Chengbo Wang, Yuanchang Liu, Xiang Chen   +3 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Nonlinear Model Predictive Control for a Dynamic Positioning Ship Based on the Laguerre Function

Journal of Marine Science and Engineering
In this paper, we present a novel nonlinear model predictive control (NMPC) algorithm based on the Laguerre function for dynamic positioning ships to solve the problems of input saturation, unknown time-varying disturbances, and heavy computation.
Xiaobin Qian, Helong Shen, Yong Yin, Dongdong Guo   +3 more
doaj   +1 more source

Post Flight Dynamic Analysis Simulation [PDF]

, 1970
Digital six-degrees-of-freedom, open loop Saturn 5 first stage flight evaluation simulation program obtains post flight simulation of the launch vehicle using actual flight data as input. Results are compared with measured data.
Gregory, B. R.
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Multiple strut-deformation patterns based analytical elastic modulus of sandwich BCC lattices

Materials & Design, 2019
This paper proposed an analytical methodology to predict the mechanical properties of sandwich body-centred cubic (BCC) lattice structures. Based on the Timoshenko beam theory, the multiple strut-deformation patterns were first introduced in the ...
Yunhui Yang, Meijuan Shan, Libin Zhao, Dexuan Qi, Jianyu Zhang   +4 more
doaj   +1 more source