Results 71 to 80 of about 5,828,755 (297)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Dynamic system simulation on the web [PDF]
, 2002 Computer simulation is the discipline of designing a model of an actual or theoretical physical system, executing the model on digital computer, and analysing the execution output.
Mahbub, Khaled
core +2 more sources
Unsupervised Band Selection Method Based on Importance-Assisted Column Subset Selection
IEEE Access, 2019 Band selection is an important preprocessing technique for hyperspectral images to select a band subset with representative information and low correlation. However, most methods focus on removing redundant components without loss of original information,
Xiaoyan Luo +3 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Facilitating insight into a simulation model using visualization and dynamic model previews [PDF]
, 2012 This paper shows how model simplification, by replacing iterative steps with unitary predictive equations, can enable dynamic interaction with a complex simulation process.
Cribbin, T, de Folter, J
core +1 more source
Bi-Level Optimization in a Transport Network
Cybernetics and Information Technologies, 2015 This paper applies a bi-level formalism for the optimal control of an urban transportation network. The well known store-and-forward model in traffic control is utilized in order to increase the control space of the optimization problem.
Stoilov Todor +3 more
doaj +1 more source
Sensors, 2019 This research focuses on the adaptive navigation of maritime autonomous surface ships (MASSs) in an uncertain environment. To achieve intelligent obstacle avoidance of MASSs in a port, an autonomous navigation decision-making model based on hierarchical ...
Xinyu Zhang +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source