Results 101 to 110 of about 158,447 (307)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Using steered molecular dynamic tension for assessing quality of computational protein structure models. [PDF]
J Comput Chem, 2022 Monroe L, Kihara D.
europepmc +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Computational form-finding methods for fabric structures [PDF]
, 2008 Form-finding is a process that determines the surface configuration of a fabric structure under prestress. This process can be carried out using a variety of numerical methods, of which the most common are (a) transient stiffness, (b) force density, and (
Lewis, W. J. (Wanda J.)
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Modelação da força de adesão em válvulas de compressores considerando fenômenos interfaciais na película de óleo lubrificante [PDF]
, 2014 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Mecânica, Florianópolis, 2014Em condições ideais, válvulas automáticas de sucção e descarga devem abrir ou fechar, de forma instantânea,
Pizarro Recabarren, Rodrigo Adrián
core
Analytical Model for Dynamic Tension in Overhead Power Transmission Lines Subject to Strong Wind [PDF]
, 2011 Dynamic tension in power transmission lines generated by wind-induced vibrations is a critical issue in the design of wind-resistant power transmission towers.
Qiang Xie, Jie Li, Dahai Wang
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Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Why does necking ignore notches in dynamic tension?
EPJ Web of Conferences, 2015 Recent experimental work has revealed that necking of tensile specimens, subjected to dynamic loading, is a deterministic phenomenon, governed by the applied boundary conditions. Furthermore it was shown that the potential sited, dictated by the boundary
Rotbaum Y., Osovski S., Rittel D.
doaj +1 more source