Results 71 to 80 of about 128,321 (246)
Using steered molecular dynamic tension for assessing quality of computational protein structure models. [PDF]
J Comput Chem, 2022 Monroe L, Kihara D.
europepmc +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Applied SciencesWire rope is a complex structure made by twisting wires of various sizes in the longitudinal direction. It is used to support or move engineering structures and is subject to various tensions.
Kwanghun Jeong +4 more
doaj +1 more source
Why does necking ignore notches in dynamic tension?
EPJ Web of Conferences, 2015 Recent experimental work has revealed that necking of tensile specimens, subjected to dynamic loading, is a deterministic phenomenon, governed by the applied boundary conditions. Furthermore it was shown that the potential sited, dictated by the boundary
Rotbaum Y., Osovski S., Rittel D.
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
EPJ Web of Conferences, 2015 The mechanical response of the carbon-epoxy material system HexPly IM7-8552 was investigated under transverse tension and combined transverse tension / in-plane shear loading at quasi-static and dynamic strain rates.
Kuhn Peter +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Metalurgija, 2016 Rheological (dynamic viscosity, flow curves) and surface properties (surface tension) of real slag system were experimentally investigated. Measurements of dynamic viscosity were performed with use of the high-temperature viscometer Anton Paar FRS 1 600.
L. Řeháčková +4 more
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