Results 141 to 150 of about 687,920 (318)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

An Adaptive Unscented Kalman Ilter Integrated Navigation Method Based on the Maximum Versoria Criterion for INS/GNSS Systems

Sensors
Aimed at the problem of navigation performance degradation in inertial navigation system/global navigation satellite system (INS/GNSS)-integrated navigation systems due to measurement anomalies and non-Gaussian measurement noise in complex navigation ...
Jiahao Zhang, Kaiqiang Feng, Jie Li, Chunxing Zhang, Xiaokai Wei   +4 more
doaj   +1 more source

Delay differential equation models for real-time dynamic substructuring [PDF]

, 2005
Real-time dynamic substructuring is a testing technique that models an entire system through the combination of an experimental test piece, representing part of the system, with a numerical model of the rest of the system.
Wagg, DJ, Wallace, MI, Neild, SA, Sieber, J, Krauskopf, B   +4 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

PSD-based intersection method for photoelectric detection of explosion position in field environments

AIP Advances
Accurate explosion localization is critical in defense research and civil blasting engineering, serving as a core technology in weapon development and controlled demolition.
Wenbo Chu, Pengfei Wang, Bin Zhang, Yuan Li, Donge Zhao   +4 more
doaj   +1 more source

Dynamic Testing of Lime-Tree (Tilia Europoea) and Pine (Pinaceae) for Wood Model Identification. [PDF]

Materials (Basel), 2020
Bragov A, Igumnov L, dell'Isola F, Konstantinov A, Lomunov A, Iuzhina T.   +5 more
europepmc   +1 more source

Tracking Testing of Dynamic Errors for Linear Guideway Based on Position Sensitive Detector [PDF]

, 2011
The dynamic precision of linear guideway is very important performance for mechatronic equipments. The dynamic errors for the linear guideway of machine tools can reduce machining precision.
Zhu SJ(朱思俊), Zhao MY(赵明扬), Zou YY(邹媛媛), Guo DZ(郭大忠)   +3 more
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

CFD based Dynamic Analysis of Atmospheric Re-Entry Vehicles [PDF]

, 2008
A Computational Fluid Dynamics analysis is undertaken to predict static- and dynamic-aerodynamic coefficients for re-entry vehicles. To determine the dynamic behavior of flying vehicles, here is presented a strategy based on the DLR CFD-TAU code with ...
Longo, José Maria, Korfanty, Marius
core