Results 161 to 170 of about 687,920 (318)
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Structurally Sound Dynamic Index Futures Hedging [PDF]
Portfolio managers use index futures for a variety of reasons. Regardless of their motivation, they will keep a close eye on the relation between the futures and their stock portfolio returns.
Patrick McGlenchy, Paul Kofman
core
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Theory testing (hypothesis testing) in agricultural economics [PDF]
According to Karl Popper, economics and agricultural economics should be deemed scientific if the theories (hypotheses) are subject to strict tests. The testing of agro-economic theories goes back 50 years in the USA, Canada, Europe, and Japan, and these
Meszaros, Sandor
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Dynamic, Welfare-Maximizing Pooled Testing [PDF]
From isolated cases to global pandemics, testing for disease is fundamental to modern medicine. However, shortages of time, testing supplies, and staff means that it is often not possible for each biological sample to be individually tested. Thus, pooled
Lopez, Nicholas Ryan
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Dynamic Testing for Evaluation of Adrenal and Gonadal Function in Pediatric and Adult Endocrinology: An Overview. [PDF]
Indian J Endocrinol Metab, 2019 Goyal A +4 more
europepmc +1 more source
Comparison of Online Visual Acuity Testing with Dynamic Dyop and Static LogMAR Optotypes in Healthy Non-Presbyopic and Presbyopic Individuals [PDF]
Reut Ifrah, Dinah Paritzky Department of Optometry, Jerusalem Multidisciplinary College, Jerusalem, IsraelCorrespondence: Reut Ifrah, Department of Optometry, Jerusalem Multidisciplinary College, 37 haneviim St, Jerusalem, 9101001, Israel, Email reutif ...
Paritzky D, Ifrah R
core +1 more source