Results 91 to 100 of about 241,913 (318)
Dynamic International Prognostic Scoring System [PDF]
, 2020 National Cancer Institute
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Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Bifurcations in a Model of Criminal Organizations and a Corrupt Judiciary
EntropyLet a population be composed of members of a criminal organization and judges of the judicial system, in which the judges can be co-opted by this organization. In this article, a model written as a set of four nonlinear differential equations is proposed
G. S. Harari, L. H. A. Monteiro
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Breaking reflection symmetry: evolving long dynamical cycles in Boolean systems
New Journal of PhysicsIn interacting dynamical systems, specific local interaction rules for system components give rise to diverse and complex global dynamics. Long dynamical cycles are a key feature of many natural interacting systems, especially in biology.
Mathieu Ouellet +5 more
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Backward bifurcation on HIV/AIDS SEI1I2TAR model with multiple interactions between sub-populations
Arab Journal of Basic and Applied SciencesThe HIV/AIDS model was dynamically analyzed in this study. The model has seven compartments: the uneducated, the educated, the HIV-positive who take antiretroviral therapy (ART), the HIV-positive who do not take ART, people receiving ART treatment ...
Ummu Habibah +3 more
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Dynamic operation of a surface water resources system [PDF]
, 2000 Cheng‐shuang Peng, Nathan Buras
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