Results 131 to 140 of about 241,913 (318)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Dynamical system analysis of interacting dark energy in LRS Bianchi type I cosmology. [PDF]

Sci Rep, 2023
Rathore S, Singh SS.
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Transfer Learning-Based Physics-Informed Convolutional Neural Network for Simulating Flow in Porous Media with Time-Varying Controls

Mathematics
A physics-informed convolutional neural network (PICNN) is proposed to simulate two-phase flow in porous media with time-varying well controls. While most PICNNs in the existing literature worked on parameter-to-state mapping, our proposed network ...
Jungang Chen, Eduardo Gildin, John E. Killough   +2 more
doaj   +1 more source

Parliamentary roll-call voting as a complex dynamical system: The case of Chile. [PDF]

PLoS One, 2023
Morales-Bader D, Castillo RD, Cox RFA, Ascencio-Garrido C.   +3 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dynamical system of a time-delayed ϕ⁶-Van der Pol oscillator: a non-perturbative approach. [PDF]

Sci Rep, 2023
Moatimid GM, Amer TS.
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A Bayesian switching linear dynamical system for estimating seizure chronotypes. [PDF]

Proc Natl Acad Sci U S A, 2022
Wang ET, Vannucci M, Haneef Z, Moss R, Rao VR, Chiang S.   +5 more
europepmc   +1 more source

Dynamic Tension Analysis for Governor Rope in Elevator System

, 2018
Mitsuhiro Yamazumi, Seiji Watanabe, Masaki Kato, Nobuyuki KOKAWA   +3 more
openalex   +1 more source