Results 61 to 70 of about 529,550 (317)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Equicontinuous factors, proximality and Ellis semigroup for Delone sets [PDF]
, 2014 We discuss the application of various concepts from the theory of topological dynamical systems to Delone sets and tilings. We consider in particular, the maximal equicontinuous factor of a Delone dynamical system, the proximality relation and the ...
Aujogue, Jean-baptiste +3 more
core +2 more sources
Generalized Integer Partitions, Tilings of Zonotopes and Lattices
, 2000 In this paper, we study two kinds of combinatorial objects, generalized integer partitions and tilings of two dimensional zonotopes, using dynamical systems and order theory.
BA Davey +12 more
core +3 more sources
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Automated global analysis of experimental dynamics through low-dimensional linear embeddings
npj ComplexityDynamical systems theory has long provided a foundation for understanding evolving phenomena across scientific domains. Yet, the application of this theory to complex real-world systems remains challenging due to issues in mathematical modeling ...
Samuel A. Moore +2 more
doaj +1 more source
Controlling complex dynamical systems based on the structure of the networks
Biophysics and Physicobiology, 2023 Progress of molecular biology resulted in the accumulation of information on biomolecular interactions, which are complex enough to be termed as networks.
Atsushi Mochizuki
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
On the Relation between Topological Entropy and Restoration Entropy
Entropy, 2018 In the context of state estimation under communication constraints, several notions of dynamical entropy play a fundamental role, among them: topological entropy and restoration entropy. In this paper, we present a theorem that demonstrates that for most
Christoph Kawan
doaj +1 more source
Thermodynamic and dynamical predictions for bifurcations and non-equilibrium phase transitions
Communications Physics, 2023 “Critical transitions”, in which systems switch abruptly from one state to another are ubiquitous in physical and biological systems. Such critical transitions in complex systems are commonly described as dynamical processes within the framework of ...
Han Yan, Feng Zhang, Jin Wang
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source