Results 81 to 90 of about 529,550 (317)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Entropy, 2012 In this paper, we combine the two universalisms of thermodynamics and dynamical systems theory to develop a dynamical system formalism for classical thermodynamics. Specifically, using a compartmental dynamical system energy flow model we develop a state-
Wassim M. Haddad
doaj +1 more source
FEBS Open Bio, EarlyView.Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu +6 more
wiley +1 more source
Information Theory and Dynamical System Predictability [PDF]
Entropy, 2011 Predicting the future state of a turbulent dynamical system such as the atmosphere has been recognized for several decades to be an essentially statistical undertaking. Uncertainties from a variety of sources are magnified by dynamical mechanisms and given sufficient time, compromise any prediction.
openaire +3 more sources
FEBS Open Bio, EarlyView.We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado +4 more
wiley +1 more source
Dynamical Systems Theory and Explanatory Indispensability [PDF]
Philosophy of Science, 2017 I examine explanations’ realist commitments in relation to dynamical systems theory. First I rebut an ‘explanatory indispensability argument’ for mathematical realism from the explanatory power of phase spaces. Then I critically consider a possible way of strengthening the indispensability argument by reference to attractors in dynamical systems theory.
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Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins
FEBS Open Bio, EarlyView.We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó +7 more
wiley +1 more source
Logical entropy of dynamical systems
Advances in Difference Equations, 2018 The main purpose of the paper is to extend the results of Ellerman (Int. J. Semant. Comput. 7:121–145, 2013) to the case of dynamical systems. We define the logical entropy and conditional logical entropy of finite measurable partitions and derive the ...
Dagmar Markechová +2 more
doaj +1 more source
Dynamic Modeling Method of Multibody System of 6-DOF Robot Based on Screw Theory [PDF]
, 2022 Jun Cheng +5 more
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