Results 61 to 70 of about 28,974 (239)

Mitochondrial Fragmentation in a High Homocysteine Environment in Diabetic Retinopathy

Antioxidants, 2022
Diabetic patients routinely have elevated homocysteine levels, and due to increase in oxidative stress, hyperhomocysteinemia is associated with increased mitochondrial damage.
Renu A. Kowluru, Ghulam Mohammad
doaj   +1 more source

A dynamin‐related protein contributes to Trichomonas vaginalis hydrogenosomal fission

The FASEB Journal, 2013
Trichomonas vaginalis is a highly divergent, unicellular eukaryote of the phylum Metamonada, class Parabasalia, and the source of a common sexually transmitted infection. This parasite lacks mitochondria, but harbors an evolutionarily related organelle, the hydrogenosome.
Yael, Wexler-Cohen, Grant C, Stevens, Eran, Barnoy, Alexander M, van der Bliek, Patricia J, Johnson   +4 more
openaire   +3 more sources

Cophosphorylation of amphiphysin I and dynamin I by Cdk5 regulates clathrin-mediated endocytosis of synaptic vesicles [PDF]

The Journal of Cell Biology, 2003
It has been thought that clathrin-mediated endocytosis is regulated by phosphorylation and dephosphorylation of many endocytic proteins, including amphiphysin I and dynamin I. Here, we show that Cdk5/p35-dependent cophosphorylation of amphiphysin I and dynamin I plays a critical role in such processes.
Tomizawa, Kazuhito, Sunada, Satoshi, Lu, Yun-Fei, Oda, Yoshiya, Kinuta, Masahiro, Ohshima, Toshio, Saito, Taro, Wei, Fan-Yan, Matsushita, Masayuki, Li, Sheng-Tian, Tsutsui, Kimiko, Hisanaga, Shin-ichi, Mikoshiba, Katsuhiko, Takei, Kohji, Matsui, Hideki   +14 more
openaire   +2 more sources

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source

Astragaloside IV Derivative (LS-102) Alleviated Myocardial Ischemia Reperfusion Injury by Inhibiting Drp1Ser616 Phosphorylation-Mediated Mitochondrial Fission

Frontiers in Pharmacology, 2020
Our previous studies showed that Astragaloside IV derivative (LS-102) exhibited potent protective function against ischemia reperfusion (I/R) injury, but little is known about the mechanisms.
Li Chen, Li Chen, Xiao-Yi Chen, Qian-Long Wang, Si-Jin Yang, Hua Zhou, Li-Sheng Ding, Lin-Sen Qing, Pei Luo   +8 more
doaj   +1 more source

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

The Plasticity of Mesenchymal Stem Cells in Regulating Surface HLA-I

iScience, 2019
Summary: A low surface expression level of human leukocyte antigen class I (HLA-I) ensures that the mesenchymal stem cells (MSCs) escape from the allogeneic recipients' immunological surveillance.
Yafei Wang, Jiayun Huang, Lin Gong, Dongsheng Yu, Chenrui An, Varitsara Bunpetch, Jun Dai, He Huang, Xiaohui Zou, Hongwei Ouyang, Hua Liu   +10 more
doaj   +1 more source

Contribution of the GTPase Domain to the Subcellular Localization of Dynamin in the NematodeCaenorhabditis elegans [PDF]

Molecular Biology of the Cell, 1998
Caenorhabditis elegans dynamin is expressed at high levels in neurons and at lower levels in other cell types, consistent with the important role that dynamin plays in the recycling of synaptic vesicles. Indirect immunofluorescence showed that dynamin is concentrated along the dorsal and ventral nerve cords and in the synapse-rich nerve ring.
A M, Labrousse, D L, Shurland, A M, van der Bliek   +2 more
openaire   +2 more sources

Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

Advanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai, Zihao Yong, Yang Li, Qingmin Chen, Yong Liu, Xiaomeng Guo, Fukai Li, Shicheng Tang, Zhuo Yang, Yufei Zhang, Ruwei Jie, Xiaohong Lv, Huacheng Wang, Chunming Huang, Liwei Xie, Jianqi Xiao, Qingchun Mu, Longguang Tang   +17 more
wiley   +1 more source

TheArabidopsisDynamin-Related Protein2 Family Is Essential for Gametophyte Development  

The Plant Cell, 2010
AbstractClathrin-mediated membrane trafficking is critical for multiple stages of plant growth and development. One key component of clathrin-mediated trafficking in animals is dynamin, a polymerizing GTPase that plays both regulatory and mechanical roles.
Steven K, Backues, David A, Korasick, Antje, Heese, Sebastian Y, Bednarek   +3 more
openaire   +3 more sources