Results 231 to 240 of about 18,529 (254)
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Brain Research, 1984
The distribution of immunoreactive (ir)-dynorphin A1-8 (Dyn A1-8) in 78 microdissected rat brain areas as well as in the neurointermediate lobe of pituitary gland was determined using a highly specific radioimmunoassay. The highest concentrations of Dyn A1-8 in brain were found in substantia nigra (673.8 fmol/mg protein) and lateral preoptic area (565 ...
Nadav Zamir +2 more
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The distribution of immunoreactive (ir)-dynorphin A1-8 (Dyn A1-8) in 78 microdissected rat brain areas as well as in the neurointermediate lobe of pituitary gland was determined using a highly specific radioimmunoassay. The highest concentrations of Dyn A1-8 in brain were found in substantia nigra (673.8 fmol/mg protein) and lateral preoptic area (565 ...
Nadav Zamir +2 more
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European Journal of Pharmacology, 1984
Peptides deriving from the proenkephalin B precursor were studied in the Ungerstedt rotational model after their unilateral injection into the substantia nigra. Dynorphin (DYN)-(1-17), DYN-(1-13) and DYN-(1-8) in 0.1-10 micrograms doses induced marked contralateral rotation.
Menek Goldstein +14 more
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Peptides deriving from the proenkephalin B precursor were studied in the Ungerstedt rotational model after their unilateral injection into the substantia nigra. Dynorphin (DYN)-(1-17), DYN-(1-13) and DYN-(1-8) in 0.1-10 micrograms doses induced marked contralateral rotation.
Menek Goldstein +14 more
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CNS Drugs, 2000
Dynorphin (DYN) is a potent endogenous opioid peptide which binds with high affinity to the κ-opioid receptor and has lower affinity for other opioid and non-opioid [N-methyl-D-aspartate (NMDA)] receptors. This pharmacological profile may explain the conflicting results obtained with DYN in experimental pain models. Most recent literature suggests that
Michael Schäfer +2 more
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Dynorphin (DYN) is a potent endogenous opioid peptide which binds with high affinity to the κ-opioid receptor and has lower affinity for other opioid and non-opioid [N-methyl-D-aspartate (NMDA)] receptors. This pharmacological profile may explain the conflicting results obtained with DYN in experimental pain models. Most recent literature suggests that
Michael Schäfer +2 more
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A monoclonal antibody specific for a dynorphin precursor
Neuropeptides, 1985Murine monoclonal antibodies were produced against dynorphin-32 (D32), a naturally occurring opioid peptide containing the sequence of dynorphin A (Dyn A) at its amino terminus, followed by Lys-Arg, then by the sequence of dynorphin B (Dyn B). Initial characterization using an enzyme-linked immunosorbent assay revealed that one clone (17.M) recognized ...
Avram Goldstein, Ronald W. Barrett
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Dynorphins regulate the strength of social memory
Neuropharmacology, 2014Emotionally arousing events like encounter with an unfamiliar con-species produce strong and vivid memories, whereby the hippocampus and amygdala play a crucial role. It is less understood, however, which neurotransmitter systems regulate the strength of social memories, which have a strong emotional component.
Daniela Mauer +3 more
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Dynorphins in regulation of immune system functions [PDF]
Biochemistry (Moscow), 2014 Dynorphins constitute a family of opioid peptides manifesting the highest affinity for κ-opiate receptors. Immune system cells are known to express a κ-receptor similar to that in the central nervous system, and as a consequence dynorphins are involved in the interaction between cells of the nervous and immune systems. In this review, data on dynorphin
S. V. Gein, S. V. Gein
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The Journal of Pharmacology and Experimental Therapeutics, 1991
In recent publications we have proposed that dynorphin (Dyn) A(1-17) functions as an antianalgesic modulator to oppose opioid-induced antinociception in mice. In the present experiments using the tail-flick response in mice, other Dyns [Dyn A(1-8), Dyn A(1-13), Dyn A(2-17), Dyn B and alpha- and beta-neoendorphin] when administered intrathecally (i.t ...
J J, Rady, J M, Fujimoto, L F, Tseng
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In recent publications we have proposed that dynorphin (Dyn) A(1-17) functions as an antianalgesic modulator to oppose opioid-induced antinociception in mice. In the present experiments using the tail-flick response in mice, other Dyns [Dyn A(1-8), Dyn A(1-13), Dyn A(2-17), Dyn B and alpha- and beta-neoendorphin] when administered intrathecally (i.t ...
J J, Rady, J M, Fujimoto, L F, Tseng
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Dynorphin A immunoreactivity in human cerebrospinal fluid
Regulatory Peptides, 1987Dynorphin A immunoreactivity in human cerebrospinal fluid has been characterized. Large quantities of the fluid were fractionated by molecular sieving on a Sephadex G-50 column and analyzed by radioimmunoassay. Active fractions were further analyzed by means of HPLC and an enzyme radioimmunoassay procedure for identification of Leu-enkephalin-Arg6 ...
Fred Nyberg, Ingrid Nylander
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Evidence for dynorphin-A as a neurotransmitter in rat hippocampus
Life Sciences, 1983The molecular forms of Dynorphin A immunoreactivity (Dyn A-IR) detected in hippocampus were resolved by reverse-phase high pressure liquid chromatography (C18-HPLC). Peptide co-eluting with synthetic Dyn A(1-17) represents 20% of the total Dyn A-IR.
Charles Chavkin +2 more
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Tissue distribution of a dynorphin-processing endopeptidase
Endocrinology, 1993A number of peptide hormones and neurotransmitters require post-translational processing at monobasic cleavage sites. An enzymatic activity capable of processing prodynorphin at a monobasic processing site has been previously reported in rat brain and bovine pituitary. This dynorphin (Dyn)-converting enzyme (DCE) activity is capable of converting Dyn-B-
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