Results 241 to 250 of about 18,529 (254)
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Characterization of immunoreactive dynorphin in human phaeochromocytomas
Journal of Endocrinology, 1988ABSTRACT The prodynorphin-derived opioids, dynorphin (DYN) and α-neoendorphin (αNE) were studied in 24 human phaeochromocytomas and related tumours. Nineteen tumours, extracted in HCl (0·1 mol/l), contained concentrations of immunoreactive DYN (ir-DYN) ranging from < 0·5 to 794 pmol/g wet weight. None of the extracts in HCl contained ir-αNE (
G. M. Besser +2 more
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Cytokine involvement in dynorphin-induced allodynia
Pain, 2000Dynorphin A is an endogenous opioid peptide, which has previously been shown to produce a long-lasting allodynia and hyperalgesia in mice, behavioral states consistent with signs of clinically observed neuropathic pain. This dynorphin-induced allodynia was used as a pharmacological, central model of neuropathic pain.
Tinna M. Laughlin +3 more
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Opioid and Nonopioid Cardiovascular Effects of Dynorphins
1996Publisher Summary The endogenous opioid peptides peptides are derived from three separate protein precursors, which upon proteolytic cleavage generate distinct classes of opioid compounds. One of these precursors is prodynorphin, which generates Dyn A, Dyn B, α- and β-neo-End, and leumorphin.
Michel Dumont, Simon Lemaire
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Dynorphin immunoreactivity in the toad neurointermediate lobe
Life Sciences, 1982Abstract The predominant immunoreactive dynorphin in the toad neurointermediate lobe was similar to that isolated from toad brain with respect to its apparent molecular weight and HPLC retention time. Specific immunoreactive dynorphin staining was present within pars nervosa but not within pars intermedia or pars distalis based on immunohistochemical
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Dynorphin antibodies bind microbial protein sequences that mimic dynorphin
Biological Psychiatry, 1994Chawki Benkelfat +3 more
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Spinal Dynorphin and Neuropathic Pain
2009The endogenous neuropeptides dynorphins are proteolytic products of prodynorphin which are characterized by their high affinity for opioid receptors. Dynorphin A is widely distributed in the CNS and in the spinal cord is found predominantly in neurons of laminae I/II and V.
Josephine Lai +2 more
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Dynorphin interaction at the κ-opiate site
European Journal of Pharmacology, 1981E. Leong Way +4 more
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