Results 121 to 130 of about 8,125 (179)

KNDy Neurons and the Control of the Gonadotropic Axis in the Midgestation Fetal Sheep.

Endocrinology
Amodei R, Jonker SS, Lazen E, Nestor CC, Estill CT, Roselli CE.   +5 more
europepmc   +1 more source

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Dynorphin A activates bradykinin receptors to maintain neuropathic pain

Nature Neuroscience, 2006
Dynorphin A is an endogenous opioid peptide that produces non-opioid receptor-mediated neural excitation. Here we demonstrate that dynorphin induces calcium influx via voltage-sensitive calcium channels in sensory neurons by activating bradykinin receptors.
Josephine, Lai, Miaw-Chyi, Luo, Qingmin, Chen, Shouwu, Ma, Luis R, Gardell, Michael H, Ossipov, Frank, Porreca   +6 more
openaire   +4 more sources

Rimorphin (dynorphin B) exists together with α-neo-endorphin and dynorphin (dynorphin A) in human hypothalamus

Biochemical and Biophysical Research Communications, 1983
Rimorphin (dynorphin B) has been demonstrated to exist together with alpha-neo-endorphin and dynorphin(1-17) (dynorphin A) in the human hypothalamus. The content of rimorphin was comparable to that of alpha-neo-endorphin and somewhat higher than that of dynorphin. This result is quite similar to the recent observations in bovine, porcine and rat neural
K, Nakao, T, Yoshimasa, M, Suda, M, Sakamoto, Y, Ikeda, K, Hayashi, H, Imura   +6 more
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Dynorphin(1–10)amide: A potent and selective analog of dynorphin(1–13)

Life Sciences, 1982
Dynorphin(1-10)amide was more potent than Dynorphin(1-13) in inhibiting the twitch of the mouse vas deferens (IC50 of Dynorphin(1-10)amide = 0.3 nM and IC50 of Dynorphin (1-13) = 4.0 nM). Binding assays indicated that two opioid peptides had similar profiles in that they enhanced dihydromorphine (DHM) binding in picomolar concentrations but displaced ...
S, Woo, J, Garzon, P, Sanchez-Blazquez, F C, Tulunay, J K, Chang, H H, Loh   +5 more
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Dynorphins other than dynorphin A(1-17) lack spinal antianalgesic activity but do act on dynorphin A(1-17) receptors.

The Journal of Pharmacology and Experimental Therapeutics, 1991
In recent publications we have proposed that dynorphin (Dyn) A(1-17) functions as an antianalgesic modulator to oppose opioid-induced antinociception in mice. In the present experiments using the tail-flick response in mice, other Dyns [Dyn A(1-8), Dyn A(1-13), Dyn A(2-17), Dyn B and alpha- and beta-neoendorphin] when administered intrathecally (i.t ...
J J, Rady, J M, Fujimoto, L F, Tseng
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Dynorphin A immunoreactivity in human cerebrospinal fluid

Regulatory Peptides, 1987
Dynorphin A immunoreactivity in human cerebrospinal fluid has been characterized. Large quantities of the fluid were fractionated by molecular sieving on a Sephadex G-50 column and analyzed by radioimmunoassay. Active fractions were further analyzed by means of HPLC and an enzyme radioimmunoassay procedure for identification of Leu-enkephalin-Arg6 ...
F, Nyberg, I, Nylander
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A monoclonal antibody specific for a dynorphin precursor

Neuropeptides, 1985
Murine monoclonal antibodies were produced against dynorphin-32 (D32), a naturally occurring opioid peptide containing the sequence of dynorphin A (Dyn A) at its amino terminus, followed by Lys-Arg, then by the sequence of dynorphin B (Dyn B). Initial characterization using an enzyme-linked immunosorbent assay revealed that one clone (17.M) recognized ...
R W, Barrett, A, Goldstein
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