Results 131 to 140 of about 8,125 (179)

Differential biotransformation of dynorphin A(1–17) and dynorphin A(1–13) peptides in human blood, ex vivo

Peptides, 1996
The biotransformation in human blood in vitro of three dynorphin A (Dyn A) peptides was studied by matrix assisted laser desorption mass spectrometry to determine whether the natural peptide, Dyn A(1-17), is biotransformed differently from Dyn A (1-13), the natural sequence shortened form used in numerous neurobiological and pharmacological studies. In
J Z, Chou, B T, Chait, R, Wang, M J, Kreek   +3 more
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Cardiovascular effects of Dynorphin A-(1–8), Dynorphin A-(1–13) and Dynorphin A-(1–17) microinjected into the preoptic medialis nucleus of the rat

Neuropeptides, 1984
Multiple forms of Dynorphin A (Dyn A) are present in cardiovascular nuclei in the hypothalamus, along with kappa-opiate receptors. To study the potential role of Dyn A in cardiovascular regulation, various Dyn A species [Dyn A-(1-8; 1-13; 1-17)] were microinjected into the preoptic nucleus (POM) of the anesthetized rat.
G, Feuerstein, A I, Faden
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Membrane Interaction of Disease-Related Dynorphin A Variants

Biochemistry, 2013
The membrane interaction properties of two single-residue variants, R6W and L5S, of the 17-amino acid neuropeptide dynorphin A (DynA) were studied by circular dichroism (CD) and nuclear magnetic resonance (NMR) spectroscopy. Corresponding gene mutations have recently been discovered in humans and causatively linked to a neurodegenerative disorder.
Johannes, Björnerås, Astrid, Gräslund, Lena, Mäler   +2 more
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Dynorphin A(6-12) Analogs Suppress Thermal Edema

Peptides, 1998
Dynorphin A (Dyn A) is a 17-residue opioid peptide derived from prodynorphin precursors found in mammalian tissues. Removal of Tyr1 from Dyn A produces a peptide that is more potent than Dyn A in attenuating the acute phase of the inflammatory response, as measured by inhibition of heat-induced edema in the anesthetized rat's paw (exposure to 58 ...
E T, Wei, H A, Thomas, E A, Gjerde, R K, Reed, S V, Burov, V I, Korolkov, O V, Glynskaya, M Y, Dorosh, G P, Vlasov   +8 more
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Tissue distribution of a dynorphin-processing endopeptidase

Endocrinology, 1993
A number of peptide hormones and neurotransmitters require post-translational processing at monobasic cleavage sites. An enzymatic activity capable of processing prodynorphin at a monobasic processing site has been previously reported in rat brain and bovine pituitary. This dynorphin (Dyn)-converting enzyme (DCE) activity is capable of converting Dyn-B-
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Comparative effects of intrahippocampal injection of dynorphin A(1–8), dynorphin A(1–13), dynorphin A(1–17), U-50,488H, and dynorphin B on blood pressure and heart rate in spontaneously hypertensive and normotensive Wistar-Kyoto rats

Peptides, 1994
We previously demonstrated centrally mediated hypotensive and bradycardic effects of dynorphin A(1-8) (DA1-8) on microinjection into various areas of the hippocampal formation (HF) of both anesthetized and conscious male normotensive and spontaneously hypertensive rats (SHR).
J Q, Wang, A J, Ingenito
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Distribution of immunoreactive dynorphin A1–8 in discrete nuclei of the rat brain: Comparison with dynorphin A

Brain Research, 1984
The distribution of immunoreactive (ir)-dynorphin A1-8 (Dyn A1-8) in 78 microdissected rat brain areas as well as in the neurointermediate lobe of pituitary gland was determined using a highly specific radioimmunoassay. The highest concentrations of Dyn A1-8 in brain were found in substantia nigra (673.8 fmol/mg protein) and lateral preoptic area (565 ...
N, Zamir, M, Palkovits, M J, Brownstein
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Evidence for dynorphin-A as a neurotransmitter in rat hippocampus

Life Sciences, 1983
The molecular forms of Dynorphin A immunoreactivity (Dyn A-IR) detected in hippocampus were resolved by reverse-phase high pressure liquid chromatography (C18-HPLC). Peptide co-eluting with synthetic Dyn A(1-17) represents 20% of the total Dyn A-IR.
C, Chavkin, C, Bakhit, F E, Bloom
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Both dynorphin A(1-17) [Des-Tyr1]dynorphin A(2-17) inhibit adenylyl cyclase activity in rat caudate putamen.

The Journal of Pharmacology and Experimental Therapeutics, 1996
In this study, the ability of a series of dynorphin peptides to inhibit adenylyl cyclase (AC) activity was determined. The endogenous ligand of the kappa opioid receptor, dynorphin A(l-17) (Dyn A(l-17)), produced a significant concentration-dependent inhibition of AC activity in membranes prepared from the caudate putamen (CPu) of naive Fischer 344 ...
L H, Claye, E M, Unterwald, A, Ho, M J, Kreek   +3 more
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Dynorphin A Processing Enzyme: Tissue Distribution, Isolation, and Characterization

Journal of Biochemistry, 1999
Limited proteolysis of the dynorphin precursor (prodynorphin) at dibasic and monobasic processing sites results in the generation of bioactive dynorphins. In the brain and neurointermediate lobe of the pituitary, prodynorphin is processed to produce alpha and beta neo endorphins, dynorphins (Dyn) A-17 and Dyn A-8, Dyn B-13, and leucine-enkephalin.
Y, Berman, L, Ageyeva, B, Veksler, D, Wood, L A, Devi   +4 more
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