Individual differences in the neuropsychopathology of addiction. [PDF]
, 2017 Drug addiction or substance-use disorder is a chronically relapsing disorder that progresses through binge/intoxication, withdrawal/negative affect and preoccupation/anticipation stages.
George, Olivier, Koob, George F
core
Prodynorphin gene deletion increased anxiety-like behaviours, impaired the anxiolytic effect of bromazepam and altered GABAA receptor subunits gene expression in the amygdala [PDF]
This study evaluated the role of prodynorphin gene in the regulation of anxiety and associated molecular mechanisms. Emotional responses were assessed using the light–dark test, elevated plus maze and social interaction tests in prodynorphin knockout ...
Femenía Cantó, Teresa +3 more
core +1 more source
N,N‐diallyl‐tyrosyl substitution confers antagonist properties on the κ‐selective opioid peptide [D‐Pro10]dynorphin A(1–11) [PDF]
, 1988 Jean Edouard Gairin +5 more
openalex +1 more source
Agonist-Induced Conformational Changes in the Ligand Binding Domain of Cyclic Nucleotide-Regulated Channels [PDF]
, 2012 Puljung, Michael C., Zagotta, William N.
core +1 more source
The One-Two Punch of Alcoholism: Role of Central Amygdala Dynorphins/Kappa-Opioid Receptors
Biological Psychiatry, 2014 Jessica L Kissler +6 more
semanticscholar +1 more source
The Use of Agonists and Antagonists in the Treatment of Opiate Addictions [PDF]
, 2015 There are dozens of different opioids available, and each one has a unique structure that allows it to produce specific responses in the body. Some of these drugs even produce responses that can help treat recovering addicts.
Weckerly, Claire
core +1 more source
Pathology and glia type specific changes of the DPP4 activity in the spinal cord contributes to the development and maintenance of hyperalgesia and shapes opioid signalling in chronic pain states [PDF]
, 2017 Altered pain sensations such as hyperalgesia and allodynia are characteristic features of various chronic pain states, and remain difficult to treat.
Alpár, Alán +14 more
core
An endogenous opioid alters neuronal plasticity to constrain cognitive flexibility. [PDF]
Mol Psychiatry, 2023 Olusakin J, Lobo MK.
europepmc +1 more source
Dynorphin B induces lateral asymmetric changes in feline spinal cord reflexes [PDF]
, 2013 Alexander I. Pilyavskii
core +1 more source
Histamine release induced by dynorphin (1-13) from rat mast cells
, 1983 Katsumi Sugiyama, Hiroaki Furuta
openalex +1 more source