Results 81 to 90 of about 199,474 (298)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Factors affecting dysbiosis of the gut microbiota in the elderly and the progress of interventions in traditional Chinese and Western medicine

Frontiers in Cellular and Infection Microbiology
As the population ages, intestinal health in the elderly has become a key area of concern, with gut microbiota dysbiosis emerging as a significant issue.
Zhi-Jun Zhang, Ru Gao, Yu-Tong Lu, Zhi-Liang Zuo, Zhi-Liang Zuo, Yu-Huan Li, Shan Liu, Si-Yuan Song, Yi Wang, Hongyan Lai   +9 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Analysis of the Relationship Between the Degree of Dysbiosis in Gut Microbiota and Prognosis at Different Stages of Primary Hepatocellular Carcinoma

Frontiers in Microbiology, 2019
Gut microbiota dysbiosis is closely associated with primary hepatocellular carcinoma (HCC). Recent studies have evaluated the early diagnosis of primary HCC through analysis of gut microbiota dysbiosis.
Jiajia Ni, Jiajia Ni, Rong Huang, Huifang Zhou, Xiaoping Xu, Xiaoping Xu, Yang Li, Yang Li, Peihua Cao, Peihua Cao, Kebo Zhong, Kebo Zhong, Mei Ge, Mei Ge, Xiaoxia Chen, Xiaoxia Chen, Baohua Hou, Min Yu, Baogang Peng, Qiao Li, Peng Zhang, Yi Gao, Yi Gao   +22 more
doaj   +1 more source

Genetic dysbiosis: How host genetic variants may affect microbial biofilms

, 2016
© 2016 by John Wiley & Sons, Inc. All rights reserved. A sensible hypothesis is that host genetic variants affect not only the individual ability to respond to microbial challenges, thus predisposing to the onset of acute microbial diseases, but also the
Nibali, L, Luigi Nibali
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Leaf microbiome dysbiosis triggered by T2SS-dependent enzyme secretion from opportunistic Xanthomonas pathogens

Nature Microbiology
Opportunistic plant pathogen Xanthomonas secretes leaf-degrading enzymes through the type-2 secretion systems that cause disease and thereby trigger changes in leaf microbiome composition.
Sebastian Pfeilmeier, Anja Werz, Marine Ote, Miriam Bortfeld-Miller, Pascal Kirner, Andreas Keppler, Lucas Hemmerle, Christoph G. Gäbelein, Gabriella C. Petti, Sarah Wolf, Christine M. Pestalozzi, J. Vorholt   +11 more
semanticscholar   +1 more source

Gut dysbiosis promotes prostate cancer progression and docetaxel resistance via activating NF-κB-IL6-STAT3 axis

Microbiome, 2022
Background The gut microbiota is reportedly involved in the progression and chemoresistance of various human malignancies. However, the underlying mechanisms behind how it exerts some effect on prostate cancer, as an extra-intestinal tumor, in a contact ...
Wei-Bo Zhong, Kai-Hui Wu, Zining Long, Xu-Min Zhou, Chuan-Fan Zhong, Shuo Wang, Hou-Hua Lai, Yufei Guo, D. Lv, Jian-Ming Lu, X. Mao   +10 more
semanticscholar   +1 more source

Deformed Wing Virus infection induces gut dysbiosis in honey bees

, 2023
Honey bee health decline represents a problem of global importance for the remarkable impact of these pollinators on the environment and human economy.
Davide Frizzera, Guido Favia, Giovanni Jesu, Andrea Becchimanzi, Giovanna De Leva, Desiderato Annoscia, Emilio Caprio, Francesco Pennacchio, Alfonso Cacace, Elisa Seffin, Ilaria Di Lelio, Francesco Nazzi, Claudia Damiani, Virginia Zanni   +13 more
core  

Mechanisms and consequences of intestinal dysbiosis [PDF]

, 2017
The composition of the gut microbiota is in constant flow under the influence of factors such as the diet, ingested drugs, the intestinal mucosa, the immune system, and the microbiota itself.
Hennet, Thierry; https://orcid.org/, Thierry Hennet, Weiss, G Adrienne, G. Adrienne Weiss, Hennet T, Weiss GA   +5 more
core   +1 more source