Results 71 to 80 of about 169,171 (302)

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review [PDF]

, 2020
Background A growing number of epidemiological studies indicate that metabolic syndrome (MetS) and its associated features play a key role in the development of certain degenerative brain disorders, including Alzheimer’s disease and vascular dementia ...
Bell, J.D., Bell, J.D., Bligh, S.W.A., Bligh, S.W.A., Katsuno, T., Katsuno, T., Parkinson, J., Parkinson, J., Shinjyo, N., Shinjyo, N.   +9 more
core   +1 more source

Fungal microbiota dysbiosis in IBD [PDF]

Gut, 2016
The bacterial intestinal microbiota plays major roles in human physiology and IBDs. Although some data suggest a role of the fungal microbiota in IBD pathogenesis, the available data are scarce. The aim of our study was to characterise the faecal fungal microbiota in patients with IBD.Bacterial and fungal composition of the faecal microbiota of 235 ...
Sokol, Harry, Leducq, Valentin, Aschard, Hugues, Pham, Hang-Phuong, Jegou, Sarah, Landman, Cecilia, Cohen, David, Liguori, Giuseppina, Bourrier, Anne, Nion-Larmurier, Isabelle, Cosnes, Jacques, Seksik, Philippe, Langella, Philippe, Skurnik, David, Richard, Mathias L, Beaugerie, Laurent   +15 more
openaire   +5 more sources

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Prevention of colitis in rats receiving palm oil on the background of dysbiosis by using quertulin

Journal of Education, Health and Sport, 2017
Aim: Identify the possibility of preventing colitis that develops in rats when consuming palm oil against dysbiosis. Materials and Methods: Antidysbiosis agent "Quertulin" (Quercetin + Inulin + Citrate Ca) was used. Biological experiments were performed
A. V. Bocharov, A. P. Levitsky, A. I. Gozhenko   +2 more
doaj   +3 more sources

Bifidobacterium longum subsp. infantis in experimental necrotizing enterocolitis: alterations in inflammation, innate immune response, and the microbiota. [PDF]

, 2014
BackgroundProbiotics decrease the risk of necrotizing enterocolitis (NEC). We sought to determine the impact of Bifidobacterium longum subsp. infantis (B. infantis) in the established rat model of NEC.MethodsRat pups delivered 1 d prior to term gestation
Arriola, Jennifer, Bevins, Charles L, Dvorak, Bohuslav, Gerber, Colin W, Kalanetra, Karen M, Kananurak, Anchasa, Kaveti, Ashwini, Mills, David A, Underwood, Mark A   +8 more
core   +1 more source

Deficiency of dietary fiber in Slc5a8-null mice promotes bacterial dysbiosis and alters colonic epithelial transcriptome towards proinflammatory milieu [PDF]

, 2019
Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the intestinal tract due to disruption of the symbiotic relationship between the host immune system and microbiota.
Elmassry, Moamen, Faruk Sikder, Mohd Omar, Ganapathy, Pramodh K., Ganapathy, Vadivel, Kottapalli, Kameswara Rao, Ramachandran, Sabarish, Sivaprakasam, Sathish   +6 more
core   +2 more sources

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Gut immune dysfunction through impaired innate pattern recognition receptor expression and gut microbiota dysbiosis in chronic SIV infection. [PDF]

, 2016
HIV targets the gut mucosa early in infection, causing immune and epithelial barrier dysfunction and disease progression. However, gut mucosal sensing and innate immune signaling through mucosal pattern recognition receptors (PRRs) during HIV infection ...
Bäumler, AJ, Dandekar, S, Gaulke, CA, Glavan, TW, Goulart, LR, Hirao, LA, Jiang, G, Raffatellu, M, Sankaran-Walters, S, Santos Rocha, C   +9 more
core   +2 more sources

Dysbiosis: from fiction to function [PDF]

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2019
Advances in data collection technologies reveal that an imbalance (dysbiosis) in the composition of host-associated microbial communities (microbiota) is linked to many human illnesses. This association makes dysbiosis a central concept for understanding how the human microbiota contributes to health and disease.
Connor R, Tiffany, Andreas J, Bäumler
openaire   +2 more sources

Mycobiota dysbiosis and gastric tumorigenesis

Theranostics, 2021
The gastrointestinal tract contains a vast and diverse microbial reservoir composed of bacteria, fungi, and viruses that contribute positively to human health. There is growing evidence that perturbation of the normal microbiota can promote a variety of human disease states that include tumorigenesis. Whether the fungal component of the gut microbiota (
Papon, Nicolas, Hohl, Tobias, Zhai, Bing
openaire   +3 more sources