Results 101 to 110 of about 5,143 (201)

Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses [PDF]

, 2017
Hearing relies on rapid, temporally precise, and sustained neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (IHCs).
Auclair, SM, Avan, P, Bahloul, A, Ciric, D, de Monvel, JB, Dulon, D, Emptoz, A, Goutman, JD, Guillon, M, Hardelin, J-P, Krishnakumar, SS, Michalski, N, Nouaille, S, Parrin, A, Petit, C, Rothman, JE, Sachse, M, Safieddine, S, Sutton, RB, Tertrais, M   +19 more
core   +1 more source

A Network‐Driven Framework for Drug Response Precision Prediction of Acute Myeloid Leukemia

Advanced Science, Volume 12, Issue 36, September 25, 2025.
A network‐based precision medicine platform, named NetAML is offered for personalized treatment of AML. It combines network analysis and machine learning to develop 87 models predicting drug sensitivity for clinical drugs. NetAML identifies interpretable gene signatures that drive differential drug responses, enabling the prediction of individual ...
Yinyin Wang, Rui Liu, Yinnan Zhang, Xiang Luo, Chengzhuang Yu, Shentong Fang, Ninghua Tan, Jing Tang   +7 more
wiley   +1 more source

Duchenne muscular dystrophy: A immunohistochemical profile and deletion pattern in dystrophin gene in North Indian population

Asian Journal of Medical Sciences, 2017
Background: Duchenne muscular dystrophy (DMD), one of the most common X linked muscular disorder, affecting 1 in 3500 male births and is caused by mutation in dystrophin gene. 65% of DMD cases are caused by large deletion of dystrophin gene, followed by
Rachna Agarwal
doaj   +1 more source

Sphingolipids in Extracellular Vesicles Released From the Skeletal Muscle Plasma Membrane Control Muscle Stem Cell Fate During Muscle Regeneration

Journal of Extracellular Vesicles, Volume 14, Issue 9, September 2025.
ABSTRACT Extracellular vesicles (EVs) represent a cytokine‐independent pathway though which skeletal muscle (SkM) cells influence the fate of neighbouring cells, thereby regulating SkM metabolic homeostasis and regeneration. Although SkM‐EVs are increasingly being explored as a therapeutic strategy to enhance muscle regeneration or to induce the ...
Rhyma Hakkar, Caroline E. Brun, Pascal Leblanc, Emmanuelle Meugnier, Emmanuelle Berger‐Danty, Olivier Blanc‐Brude, Stefano Tacconi, Audrey Jalabert, Laura Reininger, Sandra Pesenti, Catherine Calzada, Vincent Gache, Sanjay B. Vasan, Julien Pichon, Thibaut Larcher, Elizabeth Errazuriz‐Cerda, Christelle Cassin, Bong Hwan Sung, Alissa Weaver, Antonella Bongiovanni, Karl Rouger, Jean‐Paul Pais de Barros, karim Bouzakri, Sophie Rome   +23 more
wiley   +1 more source

Cytokines and chemokines as regulators of skeletal muscle inflammation: presenting the case of Duchenne muscular dystrophy [PDF]

, 2013
Duchenne muscular dystrophy is a severe inherited muscle disease that affects 1 in 3500 boys worldwide. Infiltration of skeletal muscle by inflammatory cells is an important facet of disease pathophysiology and is strongly associated with disease ...
De Bleecker, Jan, De Paepe, Boel
core   +3 more sources

Plasma POSTN Derived From Bile Proteome Is a Promising Biomarker for Cholangiocarcinoma With Efficacy Comparable and Complementary to CA19.9

United European Gastroenterology Journal, Volume 13, Issue 7, Page 1155-1170, September 2025.
ABSTRACT Background Cholangiocarcinoma presents a global health challenge due to its increasing incidence and poor prognosis, primarily resulting from delayed diagnosis. There is an urgent need for a reliable biomarker to enhance early detection. Materials and Methods Patients with cholangiocarcinoma were enrolled into three cohorts: a discovery set (n 
Lichieh Julie Chu, Chia‐Jung Tsai, Chun‐Chun Chien, Yung‐Chin Hsiao, Jau‐Song Yu, Jun‐Yi Tsai, Ta‐Sen Yeh   +6 more
wiley   +1 more source

Increased circulating levels of interleukin-6 induce perturbation in redox-regulated signaling cascades in muscle of dystrophic mice [PDF]

, 2017
Duchenne muscular dystrophy (DMD) is an X-linked genetic disease in which dystrophin gene is mutated, resulting in dysfunctional or absent dystrophin protein.
Forcina, Laura, Musaro', Antonio, Nicoletti, Carmine, Pelosi, Laura, Scicchitano, Bianca Maria   +4 more
core   +3 more sources

Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells [PDF]

, 2019
Caveolin-3 is the major structural protein of caveolae in muscle. Mutations in the CAV3 gene cause different types of myopathies with altered membrane integrity and repair, expression of muscle proteins, and regulation of signaling pathways. We show here
Bensalah, Mona, Bigot, Anne, Blouin, Cedric M., Butler-Browne, Gillian, Chambon, Valérie, Dewulf, Melissa, Johannes, Ludger, Köster, Darius, Lamaze, Christophe, Nassoy, Pierre, Negroni, Elisa, Podkalicka, Joanna, Sinha, Bidisha, Tardif, Nicolas, Viaris de Lesegno, Christine   +14 more
core   +5 more sources

Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy [PDF]

, 2018
Duchenne muscle dystrophy (DMD) is a genetic disorder characterized by progressive skeletal muscle weakness. Dystrophin deficiency induces instability of the sarcolemma during muscle contraction that leads to muscle necrosis and replacement of muscle by ...
Díaz Manera, Jordi, Escudero Cuadrado, Luis María, Fernández Simón, Esther, Gallardo, Eduard, Gómez Gálvez, Pedro, Piñol Jurado, Patricia, Suárez Calvet, Xavier   +6 more
core   +1 more source

Nanodysferlins support membrane repair and binding to TRIM72/MG53 but do not localize to t-tubules or stabilize Ca2+ signaling

Molecular Therapy: Methods & Clinical Development
Mutations in the DYSF gene, encoding the protein dysferlin, lead to several forms of muscular dystrophy. In healthy skeletal muscle, dysferlin concentrates in the transverse tubules and is involved in repairing the sarcolemma and stabilizing Ca2 ...
Joaquin Muriel, Valeriy Lukyanenko, Thomas A. Kwiatkowski, Yi Li, Sayak Bhattacharya, Kassidy K. Banford, Daniel Garman, Hannah R. Bulgart, Roger B. Sutton, Noah Weisleder, Robert J. Bloch   +10 more
doaj   +1 more source