Evidence for B cell exhaustion in chronic graft-versus-host disease [PDF]
Chronic graft-versus-host disease (cGvHD) remains a major complication of allogeneic hematopoietic stem cell transplantation (HSCT). A number of studies support a role for B cells in the pathogenesis of cGvHD.
Alousi, AM +16 more
core +2 more sources
Multiomics strategy in clinical immunology aiding unsolved antibody deficiencies [PDF]
Clinical and immunological phenotyping of a cohort of consecutive dysgammaglobulinemic patients with unknown genetic defects underwent genomic (e.g. whole-exome sequencing) and other relative multiomics (e.g.
Abolhassani, Hassan
core +1 more source
Predictive markers for humoral influenza vaccine response in patients with common variable immunodeficiency (CVID) [PDF]
BACKGROUND: A subgroup of patients with common variable immunodeficiencies (CVID) responds to vaccination. The aim of the study was to try to identify predictive markers for those who developed a humoral immune response after influenza vaccination ...
Abolhassani, H. +4 more
core +1 more source
The SLAM family receptors contribute to diverse aspects of lymphocyte biology and signal via the small adaptor molecule SAP. Mutations affecting SAP lead to X-linked lymphoproliferative syndrome Type 1, a severe immunodysregulation characterized by ...
Bonnie Huang +5 more
doaj +1 more source
Systemic Epstein–Barr Virus-Positive T/NK Lymphoproliferative Diseases With SH2D1A/XIAP Hypomorphic Gene Variants [PDF]
X-linked lymphoproliferative disease (XLP) is one of the X-linked primary immunodeficiency diseases (PIDs) with defective immune response to Epstein–Barr virus (EBV) infection.
Akira Shiraishi +7 more
core +1 more source
Follicular Helper T Cells in DiGeorge Syndrome
DiGeorge syndrome is an immunodeficiency characterized by thymic dysplasia resulting in T cell lymphopenia. Most patients suffer from increased susceptibility to infections and heightened prevalence of autoimmune disorders, such as autoimmune ...
Adam Klocperk +8 more
doaj +1 more source
National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Immune Dysregulation and Pathobiology Working Group Report [PDF]
Immune reconstitution after hematopoietic stem cell transplantation (HCT) beyond 1 year is not completely understood. Many transplant recipients who are free of graft-versus-host disease (GVHD) and not receiving any immunosuppression more than 1 year ...
Carpenter, Paul +11 more
core +1 more source
Nitroblue Tetrazolium Test in Hodgkin Disease and Other Malignant Lymphomas [PDF]
A nitroblue tertrazolium (NBT) test showed positive reactions in all of 22 patients with Hogkins disease and in nine of 12 patients with malignant lymphoma. No correlation was noted in the degree of NBT reduction, activity of the diseaeses ...
Appleby, Joseph +2 more
core +1 more source
Patients with X‐linked lymphoproliferative disease 1 (XLP1) are exquisitely susceptible to Epstein‐Barr virus (EBV), with the first EBV infection often resulting in rapid death. In a manner not previously described, a 5‐year‐old patient with XLP1 presented solely with behavioral aggression, with no laboratory evidence of organ dysfunction or ...
Michelle M. Korah-Sedgwick +2 more
wiley +1 more source
Synchronous BALT Lymphoma and Squamous Cell Carcinoma of the Lung: Coincidence or Linkage?
A 72‐year‐old man presented with weight loss, fever, and malaise. Chest radiograph and CT revealed two large ill‐defined masses in middle and left lower lobes. CT‐guided biopsy of left lower lobe mass disclosed bronchus‐associated lymphoid tissue (BALT) lymphoma. Middle lobe mass was considered second deposit in contralateral lung. The patient received
Anastasia Oikonomou +11 more
wiley +1 more source

