Results 241 to 250 of about 131,644 (347)

Efficacy and safety in tirzepatide‐treated Korean adults with type 2 diabetes—A post hoc analysis of SURPASS‐AP‐combo and SURPASS‐3

open access: yesDiabetes, Obesity and Metabolism, Volume 27, Issue 12, Page 7110-7122, December 2025.
Abstract Aims This post hoc analysis assessed the efficacy and safety data in tirzepatide‐treated Korean patients with type 2 diabetes (T2D). Materials and Methods Data specifically from Korean patients treated with tirzepatide 5, 10, or 15 mg in the multicentre, randomised, open‐label, parallel‐group, phase 3 trials SURPASS‐AP‐Combo and SURPASS‐3 were
Byung Wan Lee   +11 more
wiley   +1 more source

Coated glucose microbeads stimulate enteric hormone release and improve glucose tolerance in Phase 1 and 2 clinical trials

open access: yesDiabetes, Obesity and Metabolism, Volume 27, Issue 12, Page 7344-7354, December 2025.
Abstract Aims Incretin agonists are used to treat obesity and metabolic dysfunction. Instead of systemically delivering high levels of hormone receptor agonists that can lead to adverse effects, we tested and optimized oral microbead formulations that activate endogenous enteroendocrine signalling systems via distal nutrient‐sensing cells.
Kai Deusch   +9 more
wiley   +1 more source

Comparison of Glycemic and Anthropometric Parameters Among Patients With Dyspepsia and Dyslipidemia With or Without Helicobacter pylori Infection: A Cross-Sectional Study. [PDF]

open access: yesCureus
Serra MAA   +8 more
europepmc   +1 more source

The Effectiveness of Plecanatide for Treating Constipation and Bloating in Patients Aged 18 to 40 Years With Irritable Bowel Syndrome: Utilization of a New Composite Trisymptom Endpoint

open access: yesJournal of Gastroenterology and Hepatology, Volume 40, Issue 12, Page 2890-2897, December 2025.
ABSTRACT Background and Aim Irritable bowel syndrome with constipation (IBS‐C) is characterized by multiple sensory symptoms, including abdominal pain, bloating, and bowel habit alterations. Therapeutic response should address all components. This study assesses a new exploratory trisymptom composite efficacy endpoint in an IBS‐C population of young ...
Darren M. Brenner   +4 more
wiley   +1 more source

Effect of STW 5-II (Iberogast-N) on Tolerance to Gastric Gas in Patients With Functional Dyspepsia. The IBO-2 Study. [PDF]

open access: yesNeurogastroenterol Motil
Aguilar A   +6 more
europepmc   +1 more source

Low positive and borderline negative transglutaminase antibody levels are frequently associated with a coeliac disease diagnosis

open access: yesJournal of Internal Medicine, Volume 298, Issue 6, Page 617-625, December 2025.
Abstract Background Due to the expanding screening of coeliac disease (CeD), low positive and borderline negative serum transglutaminase 2 antibody (TGA) values are causing increasing confusion in clinical practice. Objectives To investigate the significance of these findings in a well‐defined patient cohort. Methods Altogether 311 IgA‐competent adults,
Rakel Nurmi   +7 more
wiley   +1 more source

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