Results 1 to 10 of about 17,895 (155)
Dystonia, 2023 Background: Bradykinesia has been reported in patients with dystonia. Despite this, the pathophysiological mechanisms of bradykinesia in dystonia remain largely unknown.Methods: We here performed a comprehensive literature search and reviewed clinical ...
Giulia Paparella +10 more
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British Medical Bulletin, 2017 Dystonia is a clinically heterogeneous group of hyperkinetic movement disorders. Recent advances have provided a better understanding of these conditions with significant clinical impact.Peer reviewed journals and reviews. PubMed.gov.A recent consensus classification, including the assessment of phenomenology and identification of the dystonia ...
De Pablo Fernandez, E, Warner, TT
openaire +4 more sources
Disrupted sleep in dystonia depends on cerebellar function but not motor symptoms in mice
Dystonia, 2023 Although dystonia is the third most common movement disorder, patients often also experience debilitating nonmotor defects including impaired sleep.
Luis E. Salazar Leon +7 more
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Video analysis of patients with blepharospasm and lower face dystonias
Dystonia, 2023 Background: Blepharospasm (BSP) is a focal dystonia. There is a lack of standardization in the length of time necessary to get a measure of BSP severity for rating scales.Objectives: 1) Determine the difference between evaluating the number of eye ...
Mahdieh Hosseini +4 more
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Gait and balance in cervical dystonia and dystonic head tremor
Dystonia, 2023 Background: Previous studies have found gait and balance abnormalities in patients with cervical dystonia. However, the characteristics of gait and balance in cervical dystonia with head tremors have not been ascertained.
Aparna Wagle Shukla +2 more
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Cerebellar dysfunction in rodent models with dystonia, tremor, and ataxia
Dystonia, 2023 Dystonia is a movement disorder characterized by involuntary co- or over-contractions of the muscles, which results in abnormal postures and movements. These symptoms arise from the pathophysiology of a brain-wide dystonia network.
Meike E. van der Heijden +6 more
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Dystonia, 2023 According to expert consensus, dystonia can be classified as focal, segmental, multifocal, and generalized, based on the affected body distribution. To provide an empirical and data-driven approach to categorizing these distributions, we used a data ...
J. R. Younce +17 more
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Dystonia, 2023 Background: Botulinum toxin (BoNT) injections have been found to improve pain symptoms of isolated cervical dystonia (CD). In addition to muscle relaxation at the peripheral level, few studies suggest that BoNT has effects on the central brain ...
Aparna Wagle Shukla, Robert Chen, Wei Hu
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The role of protein kinase R in dystonia
Dystonia, 2023 Dystonia is a progressive neurological motor disease with few treatment options and no cure. This review synthesizes the results of recent studies that implicate protein kinase R in mediating the molecular mechanisms of dystonia pathogenesis.
Benjamin Dodd +3 more
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Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice.
Frontiers in Cellular Neuroscience, 2013 Striatal functions depend on the activity balance between the dopamine and glutamate neurotransmissions. Glutamate inputs activate cyclin-dependent kinase 5 (Cdk5), which inhibits postsynaptic dopamine signaling by phosphorylating DARPP-32 (dopamine- and
Yukio eYamamura +9 more
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