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Optimal deep brain stimulation sites and networks for cervical vs. generalized dystonia
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance We studied deep brain stimulation effects in two types of dystonia and conclude that different specific connections between the pallidum and thalamus are responsible for optimal treatment effects.
A. Horn +24 more
semanticscholar +3 more sources
Long-Term Efficacy and Safety of Chronic Globus Pallidus Internus Stimulation in Different Types of Primary Dystonia [PDF]
, 2009 Background: Deep brain stimulation (DBS) of the globus pallidus internus (GPi) offers a very promising therapy for medically intractable dystonia. However, little is known about the long-term benefit and safety of this procedure. We therefore performed a
Bötzel, Kai +6 more
core +3 more sources
Network localization of cervical dystonia based on causal brain lesions
Brain, 2019 Cervical dystonia is a neurological disorder characterized by sustained, involuntary movements of the head and neck. Most cases of cervical dystonia are idiopathic, with no obvious cause, yet some cases are acquired, secondary to focal brain lesions ...
Daniel T Corp +2 more
exaly +2 more sources
Pathogenesis of dystonia: is it of cerebellar or basal ganglia origin? [PDF]
Journal of Neurology Neurosurgery & Psychiatry, 2017 Dystonia is a disorder of motor programmes controlling semiautomatic movements or postures, with clinical features such as sensory trick, which suggests sensorimotor mismatch as the basis. Dystonia was originally classified as a basal ganglia disease. It
R. Kaji, K. Bhatia, A. Graybiel
semanticscholar +2 more sources
Cerebellum: an explanation for dystonia? [PDF]
, 2017 Dystonia is a movement disorder that is characterized by involuntary muscle contractions, abnormal movements and postures, as well as by non-motor symptoms, and is due to abnormalities in different brain areas.
Berardelli, Alfredo, Bologna, Matteo
core +3 more sources
Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism–dystonia
Nature Communications, 2016 Although manganese is an essential trace metal, little is known about its transport and homeostatic regulation. Here we have identified a cohort of patients with a novel autosomal recessive manganese transporter defect caused by mutations in SLC39A14 ...
Karin Tuschl +2 more
exaly +2 more sources
Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice
Nature Communications, 2017 Theories of cerebellar function place the inferior olive to cerebellum connection at the centre of motor behaviour. One possible implication of this is that disruption of olivocerebellar signalling could play a major role in initiating motor disease.
Joshua J White, Roy V Sillitoe
exaly +2 more sources
Human Physiology, 2017 Psychogenic movement disorders pose a complex problem inmodern neurology that requires using the interdisciplinary approachto solve a number of questions related to classification, diagnosis,treatment, and rehabilitation. The most frequent formsof psychogenic movement disorders include tremor, dystonia,myoclonus, and gait abnormality.
O. Shavlovskaya, A. Baidauletova
semanticscholar +3 more sources
Phenomenology and classification of dystonia: A consensus update
Movement Disorders, 2013 Alberto Albanese +2 more
exaly +2 more sources
Genotype–Phenotype Relations for Isolated Dystonia Genes: MDSGene Systematic Review
Movement Disorders, 2021 This comprehensive MDSGene review is devoted to 7 genes — TOR1A, THAP1, GNAL, ANO3, PRKRA, KMT2B, and HPCA — mutations in which may cause isolated dystonia.
Lara M. Lange +17 more
semanticscholar +1 more source