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Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1988 Dystonia is a difficult problem for both the clinician and the scientist. It is sufficiently common to be seen by almost all physicians, yet uncommon enough to prevent any physician from gaining broad experience in its diagnosis and treatment. Each case represents a difficult challenge even to the specialist.
E G, McGeer, P L, McGeer
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Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins
Toxins, 2020 Blepharospasm and oromandibular dystonia are focal dystonias characterized by involuntary and often patterned, repetitive muscle contractions. There is a long history of medical and surgical therapies, with the current first-line therapy, botulinum ...
T. Hassell, D. Charles
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Putaminal mosaic visualized by tyrosine hydroxylase immunohistochemistry in the human neostriatum.
Frontiers in Neuroanatomy, 2016 Among the basal ganglia-thalamocortical circuits, the putamen plays a critical role in the ‘motor’ circuits that control voluntary movements and motor learning.
Ryoma eMorigaki, Satoshi eGoto
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Video analysis of patients with blepharospasm and lower face dystonias
Dystonia, 2023 Background: Blepharospasm (BSP) is a focal dystonia. There is a lack of standardization in the length of time necessary to get a measure of BSP severity for rating scales.Objectives: 1) Determine the difference between evaluating the number of eye ...
Mahdieh Hosseini +4 more
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Classification of Dystonia [PDF]
Life, 2022 Dystonia is a hyperkinetic movement disorder characterized by abnormal movement or posture caused by excessive muscle contraction. Because of its wide clinical spectrum, dystonia is often underdiagnosed or misdiagnosed. In clinical practice, dystonia could often present in association with other movement disorders.
Lazzaro di Biase +4 more
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American Journal of Neuroradiology, 2020 BACKGROUND AND PURPOSE: Deep brain stimulation is a well-established treatment for generalized dystonia, but outcomes remain variable. Establishment of an imaging marker to guide device targeting and programming could possibly impact the efficacy of deep
L. Okromelidze +11 more
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Striatal Vulnerability in Huntington’s Disease: Neuroprotection Versus Neurotoxicity
Brain Sciences, 2017 Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat encoding an abnormally long polyglutamine tract (PolyQ) in the huntingtin (Htt) protein.
Ryoma Morigaki, Satoshi Goto
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Disrupted sleep in dystonia depends on cerebellar function but not motor symptoms in mice
Dystonia, 2023 Although dystonia is the third most common movement disorder, patients often also experience debilitating nonmotor defects including impaired sleep.
Luis E. Salazar Leon +7 more
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FDA Approvals and Consensus Guidelines for Botulinum Toxins in the Treatment of Dystonia
Toxins, 2020 In 2016, the American Academy of Neurology (AAN) published practice guidelines for botulinum toxin (BoNT) in the treatment of blepharospasm, cervical dystonia, adult spasticity, and headache. This article, focusing on dystonia, provides context for these
Lauren L Spiegel +2 more
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X-linked Dystonia-Parkinsonism patient cells exhibit altered signaling via nuclear factor-kappa B
Neurobiology of Disease, 2017 X-linked Dystonia-Parkinsonism (XDP) is a progressive neurodegenerative disease involving the loss of medium spiny neurons within the striatum. An XDP-specific haplotype has been identified, consisting of seven sequence variants which cluster around the ...
Christine A. Vaine +7 more
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