Results 21 to 30 of about 48,941 (303)
Striatal Vulnerability in Huntington’s Disease: Neuroprotection Versus Neurotoxicity
Brain Sciences, 2017 Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat encoding an abnormally long polyglutamine tract (PolyQ) in the huntingtin (Htt) protein.
Ryoma Morigaki, Satoshi Goto
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Classification of Dystonia [PDF]
Life, 2022 Dystonia is a hyperkinetic movement disorder characterized by abnormal movement or posture caused by excessive muscle contraction. Because of its wide clinical spectrum, dystonia is often underdiagnosed or misdiagnosed. In clinical practice, dystonia could often present in association with other movement disorders.
Lazzaro di Biase +4 more
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Dystonia, 2023 Background: Spinocerebellar ataxia 17 (SCA17) is a rare autosomal dominant trinucleotide disorder. There are no effective therapies for addressing the clinical symptoms of SCA17.Case report: We describe a 46-year-old male who presented with symptoms of ...
Aparna Wagle Shukla +3 more
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Non-motor symptoms in dystonia: from diagnosis to treatment
Dystonia, 2023 The Dystonia Medical Research Foundation organized an expert virtual workshop in March 2023 to review the evidence on non-motor symptoms across the spectrum of dystonia, discuss existing assessment methods, need for their harmonisation and roadmap to ...
Kathryn J. Peall +20 more
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Piecing together a complex puzzle: 5 key challenges in basic dystonia research
Dystonia, 2023 Dystonia refers to a heterogeneous group of movement disorders characterized by involuntary, sustained muscle contractions leading to repetitive twisting movements and abnormal postures.
Mariangela Scarduzio +3 more
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Schizophrenia Bulletin, 1999 This paper provides an overview of the phenomenology, epidemiology, and treatment of tardive dystonia. Tardive dystonia is one of the extrapyramidal syndromes that starts after long-term use of dopamine receptor antagonists. The diagnosis is based on the presence of chronic dystonia, defined as a syndrome of sustained muscle contractions, frequently ...
van Harten, P.N., Kahn, R.S.
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Functional imaging of deep brain stimulation in dystonia: a review
Dystonia, 2023 Much remains to be learned about the mechanism of benefit of deep brain stimulation in movement disorders in general and dystonia specifically. A full accounting of the pathophysiology of dystonia additionally remains unclear.
Ian O. Bledsoe, Melanie A. Morrison
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Spinal dystonia and other spinal movement disorders
Dystonia, 2023 While traditionally considered a disorder of the basal ganglia, brainstem, and cerebellum, multiple reports have shown that spinal cord pathologies may lead to dystonia.
Shlok Sarin +4 more
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Movement Disorders Clinical Practice, 2018 View Supplementary Video ...
Ritu Shree +2 more
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Machine Learning for Real-Time, Automatic, and Early Diagnosis of Parkinson's Disease by Extracting Signs of Micrographia from Handwriting Images [PDF]
arXiv, 2021 Parkinson's disease (PD) is debilitating, progressive, and clinically marked by motor symptoms. As the second most common neurodegenerative disease in the world, it affects over 10 million lives globally. Existing diagnoses methods have limitations, such as the expense of visiting doctors and the challenge of automated early detection, considering that
arxiv