Results 41 to 50 of about 48,941 (303)

Upconversion‐Based Remote Deep Brain Modulation for Therapeutic Dissection of Parkinson's Disease

Advanced Therapeutics, EarlyView.
An upconversion‐based wireless optogenetic strategy enables an all‐optical deep brain modulation solution for treating Parkinson's disease in rodent animals without using electronics or any tethered cables, providing experimental evidence supporting a therapeutic mechanism of STN‐DBS by disruption of anterograde signal transmission along the indirect ...
Wenchong Zhang, Xudong Lin, Kai Xie, Zixun Wang, Tianying Sun, Zhen Xu, Haibing Yue, Xi Chen, Qinghai Liao, Ming Liu, Wing Ho Yung, Jufang He, Feng Wang, Peng Shi   +13 more
wiley   +1 more source

Micro‐Coil Neuromodulation at Single‐Cell and Circuit Levels for Inhibiting Natural Neuroactivity, Neutralizing Electric Neural Excitation, and Suppressing Seizures

Advanced Science, EarlyView.
Micromagnetic stimulation (µMS) offers a precise method for neural inhibition, complementing existing neuromodulation techniques. Using an implantable micro‐coil device, µMS selectively suppresses cortical activity with high spatial resolution. It effectively counteracts micro‐electrode stimulation and reduces seizure amplitude, highlighting its ...
Kayeon Kim, Xiyuan Liu, Bingdong Chang, Guanghui Li, Gwendoline A. E. Anand, Su Genelioglu, Alexandra Katherine Isis Yonza, Andrew J Whalen, Rune W Berg, Shelley I Fried, Anpan Han, Changsi Cai   +11 more
wiley   +1 more source

Tremor in cervical dystonia

Dystonia
Background: Cervical dystonia (CD) is the most common form of focal dystonia encountered in the clinic. Approximately one-third of CD patients have co-existing tremor in the head and hands.
Sinem Balta Beylergil, Krishna Nikhil Mukunda, Mohamed Elkasaby, Joel S. Perlmutter, Stewart Factor, Tobias Bäumer, Jeanne Feurestein, Erika Shelton, Steven Bellows, Joseph Jankovic, Abhimanyu Mahajan, Tila Wamer-Rosen, Stephen G. Reich, Aparna Wagle Shukla, Irene Malaty, Alberto Espay, Kevin Duque, Mark S. LeDoux, Rachel Saunders-Pullman, Katherine Leaver, Samuel Frank, Alexander Pantelyat, Victor Fung, Sarah Pirio Richardson, Brian Berman, Natividad Stover, Andres Deik, William Ondo, Christopher Groth, Hyder A. Jinnah, Aasef G. Shaikh   +30 more
doaj   +1 more source

Case Series: Dystonia with multiple sclerosis and neuromyelitis optica

Dystonia, 2023
Dystonia is an uncommon complication of relapsing-remitting multiple sclerosis (MS) and related disorders. The types of dystonia described associated with MS are heterogenous, and the relationship between dystonia and MS remains unclear.
Helen Hwang, Victoria A. Levasseur, Joel S. Perlmutter   +2 more
doaj   +1 more source

KMT2B-related disorders: expansion of the phenotypic spectrum and long-term efficacy of deep brain stimulation [PDF]

Brain. 2020 Dec 5;143(11):3242-3261
Heterozygous mutations in KMT2B are associated with an early-onset, progressive, and often complex dystonia (DYT28). Key characteristics of typical disease include focal motor features at disease presentation, evolving through a caudocranial pattern into generalized dystonia, with prominent oromandibular, laryngeal, and cervical involvement.
arxiv   +1 more source

Detecting the Difficult: An Intronic NPC1 Variant Hiding in Plain Sight

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT An illustration of the importance of manual data review for identifying rare intronic variants adjacent to homopolymers is presented here. A 14‐year‐old male with Niemann‐Pick Type C disease confirmed biochemically was only found to have a heterozygous pathogenic variant by molecular analysis. A manual review of the Next Generation Sequencing (
Caroline Gully Brown, Matthew Bower, Matthew Schomaker, Jessica Goldstein, Jeanine Jarnes, Chester B. Whitley, Nishitha R. Pillai   +6 more
wiley   +1 more source

Deconstructing motor and non-motor aspects of dystonia with neuroimaging

Dystonia, 2023
Dystonia, the third most common movement disorder, is clinically characterized by involuntary muscle contractions leading to abnormal, patterned movements and postures that are often activated or worsened by initiation of movement.
Abhimanyu Mahajan
doaj   +1 more source

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases

BioEssays, EarlyView.
Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley   +1 more source

Analysis of Neural Clusters due to Deep Brain Stimulation Pulses [PDF]

arXiv, 2020
Deep brain stimulation (DBS) is an established method for treating pathological conditions such as Parkinson's disease, dystonia, Tourette syndrome, and essential tremor. While the precise mechanisms which underly the effectiveness of DBS are not fully understood, theoretical studies of populations of neural oscillators stimulated by periodic pulses ...
arxiv  

Clinical and anatomical characteristics of basal temporal seizures: A systematic review

Epileptic Disorders, EarlyView.
Abstract This review aimed to characterize the clinical semiology and anatomical correlates of seizures originating in the basal temporal region, an underrecognized epilepsy subtype, and to identify features that distinguish it from other forms of temporal lobe epilepsies (TLE).
Fabrice Bartolomei, Francesca Pizzo, Stanislas Lagarde   +2 more
wiley   +1 more source