Results 111 to 120 of about 18,651,759 (343)

E-Cadherin Downregulation is Mediated by Promoter Methylation in Canine Prostate Cancer

Frontiers in Genetics, 2019
E-cadherin is a transmembrane glycoprotein responsible for cell-to-cell adhesion, and its loss has been associated with metastasis development. Although E-cadherin downregulation was previously reported in canine prostate cancer (PC), the mechanism ...
Carlos Eduardo Fonseca-Alves, Carlos Eduardo Fonseca-Alves, Priscila Emiko Kobayashi, Antonio Fernando Leis-Filho, Patricia de Faria Lainetti, Valeria Grieco, Hellen Kuasne, Silvia Regina Rogatto, Renee Laufer-Amorim   +8 more
doaj   +1 more source

Slug-upregulated miR-221 promotes breast cancer progression through suppressing E-cadherin expression

Scientific Reports, 2016
It is generally regarded that E-cadherin is downregulated during tumorigenesis via Snail/Slug-mediated E-cadherin transcriptional reduction. However, this transcriptional suppressive mechanism cannot explain the failure of producing E-cadherin protein in
Yi Pan, Jing Li, Yaqin Zhang, Nan Wang, Hongwei Liang, Yuan Liu, Chen-Yu Zhang, Ke Zen, H. Gu   +8 more
semanticscholar   +1 more source

Human Brain Vasculature‐on‐a‐Chip Model Constructed With Microvessels Isolated From Cryopreserved Postmortem Human Brain Tissue

Advanced Healthcare Materials, EarlyView.
This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady, A. Scott McCall, Samuel Cullison, Daniel Chavarria, Matthew S. Schrag, Ethan S. Lippmann   +5 more
wiley   +1 more source

HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer

Journal of experimental & clinical cancer research : CR, 2016
Epithelial-mesenchymal transition (EMT) is a dedifferentiation process that mainly involves in mesenchymal marker upregulation, epithelial maker downregulation and cell polarity loss.
Jian Yang, Xu Zhang, Yi Zhang, Dongming Zhu, Lifeng Zhang, Ye Li, Yanbo Zhu, Dechun Li, Jian Zhou   +8 more
semanticscholar   +1 more source

Highly Tunable and Cell‐Remodelable Thiol‐ene Alginate‐Peptide Crosslinked Hydrogels to Recreate Cellular and Organoid Microenvironments for Biofabrication

Advanced Healthcare Materials, EarlyView.
Norbornene‐functionalized alginate is crosslinked with a di‐thiolated peptide sequence cleavable by cell‐secreted matrix metalloproteinases and decorated with cell‐adhesion peptides upon exposure to UV. Thyroid follicles, endometrial and intestinal organoids are encapsulated in a gentle manner with high cell viability and correct phenotype ...
Julia Fernández‐Pérez, Adrián Seijas‐Gamardo, Antonio J. Feliciano, Panagiota Kakni, Anna M. Kip, Paul Wieringa, Stefan Giselbrecht, Matthew B. Baker, Lorenzo Moroni   +8 more
wiley   +1 more source

Platelet‐activating factor increases mucosal permeability in rat intestine via tyrosine phosphorylation of E‐cadherin [PDF]

, 2000
Xiao‐Di Tan, Hong Chang, Xiao‐Wu Qu, Michael S. Caplan, Frank González-Crussí, Wei Hsueh   +5 more
openalex   +1 more source

Three mechanisms control E-cadherin localization to the zonula adherens

Nature Communications, 2016
E-cadherin localization to the zonula adherens is fundamental for epithelial differentiation but the mechanisms controlling localization are unclear. Using the Drosophila follicular epithelium we genetically dissect E-cadherin transport in an in vivo ...
Innokenty Woichansky, C. Beretta, N. Berns, V. Riechmann   +3 more
semanticscholar   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

A Synovium‐on‐Chip Platform to Study Multicellular Interactions in Arthritis

Advanced Healthcare Materials, EarlyView.
The Synovium‐on‐Chip comprises a thin microporous PDMS membrane to support co‐culture of fibroblast‐like synoviocytes (FLS), THP‐1‐derived macrophages, and endothelial cells, enabling real‐time analysis of synovial‐vascular interactions. FLS migration through the pores drives endothelial remodeling, while TNF‐α stimulation induces robust inflammatory ...
Laurens R. Spoelstra, Fleur R. Semmekrot, Nuno Araújo‐Gomes, Daniël Wijnperle, Monique M. A. Helsen, Martijn H.J. Van Den Bosch, Loes. I. Segerink, Séverine Le Gac, Marcel Karperien   +8 more
wiley   +1 more source

E-cadherin Expression in Invasive Mammary Carcinoma

Medical Journal of Babylon
Background:E-cadherin is an adhesion molecule that is frequently expressed in normal epithelial tissues. It is essential for many cellular processes, including organ formation, stratification, and epithelial polarization.
Alaa Abdulqader Abdulrazaq
doaj   +1 more source