Results 211 to 220 of about 164,060 (248)

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

E-cadherin endocytosis promotes non-canonical EGFR:STAT signalling to induce cell death and inhibit heterochromatinisation. [PDF]

PLoS Genet
Ramirez Moreno M, Quinton A, Jacobsen E, Stempor PA, Zeidler MP, Bulgakova NA.   +5 more
europepmc   +1 more source

Lysyl Oxidase Reduces Neutrophil Extravasation in Response to P. aeruginosa in an Infection‐on‐a‐Chip Model

Advanced NanoBiomed Research, EarlyView.
Lysyl oxidase crosslinking of type I collagen decreases neutrophil extravasation through an endothelium during the initial response to P. aeruginosa. This decrease in extravasation is likely due to the increase in VE‐cadherin expression between endothelial cells seeded on LOX‐crosslinked collagen hydrogels.
Christopher J. Calo, Tanvi Patil, Josephine Fouts, Eric L. Ginter, Margaret Radke, Hannah K. Weppner, Justin M. Owens, Laurel E. Hind   +7 more
wiley   +1 more source

Role of <i>CDH1</i> gene variants and E-cadherin localization in gastric mucosal cancerization. [PDF]

Front Oncol
Wu Y, Zhang Y, Dai Y, Luo Q, Lan S, Chen X, Chen W, Li R, Hu L.   +8 more
europepmc   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Expression profiles of E-cadherin and N-cadherin in endometriosis and other gynecological diseases towards targeted treatment: a systematic review. [PDF]

Obstet Gynecol Sci
Adamyan L, Pivazyan L, Obosyan L, Kurbatova K, Platonova E, Mailova K, Stepanian A.   +6 more
europepmc   +1 more source

Publisher Correction: Targeting GRPR for sex hormone-dependent cancer after loss of E-cadherin. [PDF]

Nature
Raymond JH, Aktary Z, Pouteaux M, Petit V, Luciani F, Wehbe M, Gizzi P, Bourban C, Decaudin D, Nemati F, Martianov I, Davidson I, Tomasetto CL, White RM, Mahuteau-Betzer F, Vergier B, Larue L, Delmas V.   +17 more
europepmc   +1 more source

E-Cadherin Is Important in the In Vitro Postnatal Development and Function of Pig Islets. [PDF]

Biomedicines
Purich K, Silva JR, Huang W, Wickware J, Williams T, Black A, Kim J, Chapa DF, Bhavanam S, Bigam D, Schiller D, Rayat GR.   +11 more
europepmc   +1 more source

E-cadherin expression and tumor-stroma ratio as prognostic biomarkers of peritoneal recurrence in advanced gastric cancer: a digital image analysis-based stratification study. [PDF]

J Pathol Transl Med
Lee S, Kim B.
europepmc   +1 more source

[Retracted] Expression and clinical significance of hypoxia‑inducible factor 1α, Snail and E‑cadherin in human ovarian cancer cell lines. [PDF]

Mol Med Rep
Zhang Y, Fan N, Yang J.
europepmc   +1 more source