Results 51 to 60 of about 239,622 (310)
Characterizing interactions in E-cadherin assemblages
Biophysical Journal, 2023 Cadherin intermolecular interactions are critical for cell-cell adhesion and play essential roles in tissue formation and the maintenance of tissue structures. In this study, we focus on E-cadherin, a classical cadherin that connects epithelial cells, to understand how they interact in cis and trans conformations when attached to the same cell or ...
Sayane Shome +3 more
openaire +4 more sources
Down regulation of E-Cadherin (ECAD) - a predictor for occult metastatic disease in sentinel node biopsy of early squamous cell carcinomas of the oral cavity and oropharynx [PDF]
, 2011 Background Prognostic factors in predicting occult lymph node metastasis in patients with head and neck squamous-cell carcinoma (HNSCC) are necessary to improve the results of the sentinel lymph node procedure in this tumour type.
Gerhard F Huber +9 more
core +1 more source
Transcriptional repression of E-cadherin by human papillomavirus type 16 E6. [PDF]
PLoS ONE, 2012 There is increasing evidence supporting DNA virus regulation of the cell adhesion and tumour suppressor protein, E-cadherin. We previously reported that loss of E-cadherin in human papillomavirus (HPV) type 16-infected epidermis is contributed to by the ...
Zarina J D'Costa +5 more
doaj +1 more source
Cancer: leaping the E‐cadherin hurdle [PDF]
The EMBO Journal, 2015 Aberrant activation of the Wnt signaling pathway is a common cause of colon cancer and other tumor types, accomplishing many of the hallmarks of cancer including sustained proliferative signaling, replicative immortality, reprogrammed metabolism, angiogenesis, and invasion.
Chen, GT, Waterman, ML
openaire +4 more sources
Tumor suppressor gene E-cadherin and its role in normal and malignant cells [PDF]
, 2003 E-cadherin tumor suppressor genes are particularly active area of research in development and tumorigenesis. The calcium-dependent interactions among E-cadherin molecules are critical for the formation and maintenance of adherent junctions in areas of ...
Pećina-Šlaus Nives
core +2 more sources
Clinicopathologic Correlations of E-cadherin and Prrx-1 Expression Loss in Hepatocellular Carcinoma [PDF]
, 2016 BACKGROUND: Developing predictive markers for hepatocellular carcinoma (HCC) is important, because many patients experience recurrence and metastasis.
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core +2 more sources
Indonesian Biomedical Journal, 2021 BACKGROUND: The absence of potential biomarkers to detect the metastatic process at an early stage will consequently delay colorectal cancer (CRC) treatment.
Winarko Luminturahardjo +4 more
doaj +1 more source
The Role of TWIST in Ovarian Epithelial Cancers [PDF]
, 2014 BACKGROUND: Epithelial-mesenchymal transition (EMT) is associated with tumor hypoxia. EMT is regulated, in part, by the action of TWIST, which inhibits of E-cadherin expression and may interfere with the p53 tumor-suppressor pathway.
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core +1 more source
There are four dynamically and functionally distinct populations of E-cadherin in cell junctions
Biology Open, 2015 E-cadherin is a trans-membrane tumor suppressor responsible for epithelial cell adhesion. E-cadherin forms adhesive clusters through combined extra-cellular cis- and trans-interactions and intracellular interaction with the actin cytoskeleton.
Zahra Erami +4 more
doaj +1 more source
Paranuclear E-Cadherin in Gastric Adenocarcinoma [PDF]
American Journal of Clinical Pathology, 2002 Decreased E-cadherin expression permits dissociation and widespread dissemination of gastric adenocarcinoma cells. We studied the relationship between paranuclear E-cadherin distribution and the histopathologic characteristics of gastric adenocarcinomas.
Philip M, Carpenter +2 more
openaire +2 more sources