Results 41 to 50 of about 174,214 (265)

5-Azacytidine Enhancing Expression of E-cadherin in Adenocarcinoma Cell Line

Archives of Advances in Biosciences, 2023
Introduction: In this study, we assessed the expression of E-cadherin in HT29 cell line treated with 5-Azacytidine and colorectal cancer patient in an Iranian population. E-cadherin expression promotes metastasis and prognosis of colorectal cancer (CRC).
Sanaz Savabkar, Shiva Irani, Reza Mirfakhraie, Masoud Alebouyeh, Hamid Asadzadeh aghdaei   +4 more
doaj   +1 more source

The Tumor-Suppressor Function of E-Cadherin [PDF]

The American Journal of Human Genetics, 1998
The transition from benign tumors to invasive, metastatic cancer cells involves changes in the extracellular matrix environment, cell motility, and cell-cell adhesion. Because cell-cell–adhesion molecules are dynamically regulated during human carcinogenesis, they have been implicated in tumorigenesis, especially during the later stages of tumor ...
Semb, Henrik, Christofori, Gerhard
openaire   +2 more sources

Allosteric Regulation of E-Cadherin Adhesion [PDF]

Journal of Biological Chemistry, 2015
Cadherins are transmembrane adhesion proteins that maintain intercellular cohesion in all tissues, and their rapid regulation is essential for organized tissue remodeling. Despite some evidence that cadherin adhesion might be allosterically regulated, testing of this has been hindered by the difficulty of quantifying altered E-cadherin binding affinity
Nitesh, Shashikanth, Yuliya I, Petrova, Seongjin, Park, Jillian, Chekan, Stephanie, Maiden, Martha, Spano, Taekjip, Ha, Barry M, Gumbiner, Deborah E, Leckband   +8 more
openaire   +2 more sources

Expression of e-cadherin, n-cadherin and snail and their correlation with clinicopathological variants: an immunohistochemical study of 132 invasive ductal breast carcinomas in Egypt

Clinics, 2011
OBJECTIVE: To evaluate the expression of the cell adhesion molecules E-cadherin and N-cadherin and the transcription factor Snail in invasive ductal breast carcinomas and to determine their relationships with clinicopathological features.
Hanan Mohamed Abd ElMoneim, Nasser Mohammed Zaghloul   +1 more
doaj   +1 more source

Transcriptional repression of E-cadherin by human papillomavirus type 16 E6. [PDF]

PLoS ONE, 2012
There is increasing evidence supporting DNA virus regulation of the cell adhesion and tumour suppressor protein, E-cadherin. We previously reported that loss of E-cadherin in human papillomavirus (HPV) type 16-infected epidermis is contributed to by the ...
Zarina J D'Costa, Carol Jolly, Elliot J Androphy, Andrew Mercer, Charles M Matthews, Merilyn H Hibma   +5 more
doaj   +1 more source

E-cadherin is transcriptionally activated via suppression of ZEB1 transcriptional repressor by small RNA-mediated gene silencing. [PDF]

PLoS ONE, 2011
RNA activation has been reported to be induced by small interfering RNAs (siRNAs) that act on the promoters of several genes containing E-cadherin. In this study, we present an alternative mechanism of E-cadherin activation in human PC-3 cells by siRNAs ...
Minami Mazda, Kenji Nishi, Yuki Naito, Kumiko Ui-Tei   +3 more
doaj   +1 more source

There are four dynamically and functionally distinct populations of E-cadherin in cell junctions

Biology Open, 2015
E-cadherin is a trans-membrane tumor suppressor responsible for epithelial cell adhesion. E-cadherin forms adhesive clusters through combined extra-cellular cis- and trans-interactions and intracellular interaction with the actin cytoskeleton.
Zahra Erami, Paul Timpson, Wu Yao, Ronen Zaidel-Bar, Kurt I. Anderson   +4 more
doaj   +1 more source

Signaling and Mechanical Roles of E-cadherin [PDF]

Cell Communication & Adhesion, 2013
The epithelium comprises an important tissue that lines the internal and external surfaces of metazoan organs. In order to organize sheets of epithelial cells into three-dimensional tissues, it requires the coordination of basic cellular processes such as polarity, adhesion, growth, and differentiation.
Tanay, Bhatt, Abrar, Rizvi, Surya Prakash Rao, Batta, Sunny, Kataria, Colin, Jamora   +4 more
openaire   +2 more sources

Microtubules Inhibit E-Cadherin Adhesive Activity by Maintaining Phosphorylated p120-Catenin in a Colon Carcinoma Cell Model. [PDF]

PLoS ONE, 2016
Tight regulation of cadherin-mediated intercellular adhesions is critical to both tissue morphogenesis during development and tissue homeostasis in adults.
Stephanie L Maiden, Yuliya I Petrova, Barry M Gumbiner   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source