N-terminal 1-54 amino acid sequence and Armadillo repeat domain are indispensable for P120-catenin isoform 1A in regulating E-cadherin. [PDF]
PLoS ONE, 2012 P120-catenin (p120ctn) exerts important roles in regulating E-cadherin and invasiveness in cancer cells. However, the mechanisms by which p120ctn isoforms 1 and 3 modulate E-cadherin expression are poorly understood.
Juanhan Yu +7 more
doaj +1 more source
5-Azacytidine Enhancing Expression of E-cadherin in Adenocarcinoma Cell Line
Archives of Advances in Biosciences, 2023 Introduction: In this study, we assessed the expression of E-cadherin in HT29 cell line treated with 5-Azacytidine and colorectal cancer patient in an Iranian population. E-cadherin expression promotes metastasis and prognosis of colorectal cancer (CRC).
Sanaz Savabkar +4 more
doaj +1 more source
E-cadherin, guardian of liver physiology [PDF]
Clinics and Research in Hepatology and Gastroenterology, 2015 E-cadherin is a cell-to-cell adhesion molecule involved in epithelial cell behavior, tissue formation and cancer suppression. In the liver, E-cadherin is expressed by hepatocytes and biliary epithelial cells. However, the exact role of E-cadherin in hepatic pathophysiology remains largely unknown.
Gonzalez-Sanchez, Ester +3 more
openaire +3 more sources
Endothelin-1 Drives Epithelial-Mesenchymal Transition In Hypertensive Nephroangiosclerosis [PDF]
, 2016 BACKGROUND: Tubulointerstitial fibrosis, the final outcome of most kidney diseases, involves activation of epithelial mesenchymal transition (EMT). Endothelin‐1 (ET‐1) activates EMT in cancer cells, but it is not known whether it drives EMT in the kidney.
Belloni, Anna S +13 more
core +1 more source
Clinics, 2011 OBJECTIVE: To evaluate the expression of the cell adhesion molecules E-cadherin and N-cadherin and the transcription factor Snail in invasive ductal breast carcinomas and to determine their relationships with clinicopathological features.
Hanan Mohamed Abd ElMoneim +1 more
doaj +1 more source
E-cadherin is transcriptionally activated via suppression of ZEB1 transcriptional repressor by small RNA-mediated gene silencing. [PDF]
PLoS ONE, 2011 RNA activation has been reported to be induced by small interfering RNAs (siRNAs) that act on the promoters of several genes containing E-cadherin. In this study, we present an alternative mechanism of E-cadherin activation in human PC-3 cells by siRNAs ...
Minami Mazda +3 more
doaj +1 more source
E-cadherin expression in thymomas
Yonsei Medical Journal, 1998 For the purpose of investigating the pattern of E-cadherin (E-CD) expression in thymomas, 72 cases were immunostained using monoclonal antibody (HECD-1) and microwave-enhanced immunohistochemical method on formalin-fixed, paraffin-embedded tissue sections. The thymomas were classified according to modified Müller-Hermelink classification.
W I, Yang +3 more
openaire +3 more sources
E-Cadherin Engagement Stimulates Tyrosine Phosphorylation [PDF]
Cell Adhesion and Communication, 1997 Cadherins are cell adhesion molecules concentrated at intercellular adherens junctions, where they form a multiprotein complex with cytoplasmic catenins. Although cell-cell interactions affect many aspects of cell behavior, little is known about signaling pathways triggered by cadherin engagement.
M S, Kinch +3 more
openaire +2 more sources
PRL-3 and E-cadherin show mutual interactions and participate in lymph node metastasis formation in gastric cancer [PDF]
, 2014 E-cadherin, a transmembrane adhesion molecule, and phosphatase of regenerating liver 3 (PRL-3) protein, a member of the family of tyrosine phosphatases, seem to be responsible for cancer cell migration.
Andrzej Kemona +4 more
core +1 more source
Microtubules Inhibit E-Cadherin Adhesive Activity by Maintaining Phosphorylated p120-Catenin in a Colon Carcinoma Cell Model. [PDF]
PLoS ONE, 2016 Tight regulation of cadherin-mediated intercellular adhesions is critical to both tissue morphogenesis during development and tissue homeostasis in adults.
Stephanie L Maiden +2 more
doaj +1 more source