Regulation of classical cadherin membrane expression and F-actin assembly by alpha-catenins, during Xenopus embryogenesis. [PDF]
PLoS ONE, 2012 Alpha (α)-E-catenin is a component of the cadherin complex, and has long been thought to provide a link between cell surface cadherins and the actin skeleton.
Sumeda Nandadasa +4 more
doaj +1 more source
Regulation of E-cadherin [PDF]
Breast Cancer Online, 2005 Numerous studies suggest that loss of E-cadherin is necessary to induce Epithelial–mesenchymal transition (EMT) and metastasis. Snail is a major contributor to EMTs. The Snail family of zinc-finger transcription factors interact with the E-cadherin promoter to repress transcription during EMT.
Z. Yang, H. Zhang, R. Kumar
openaire +1 more source
Activation of phosphatidylinositol 3-kinase/Akt signaling by EGF downregulates membranous E-cadherin and â-catenin and enhances invasion in nasopharyngeal carcinoma cells. [PDF]
, 2012 Dysregulation of E-cadherin and β-catenin function in cell-cell adhesion is common in nasopharyngeal carcinoma (NPC) and correlates with metastatic disease.
Seow, Heng Fong, Wai, Kien Yip
core +1 more source
Misregulated E-cadherin expression associated with an aggressive brain tumor phenotype. [PDF]
PLoS ONE, 2010 Cadherins are essential components of the adherens junction complexes that mediate cell-cell adhesion and regulate cell motility. During tissue morphogenesis, changes in cadherin expression (known as cadherin switching) are a common mechanism for ...
Laura J Lewis-Tuffin +6 more
doaj +1 more source
Dynamic microtubules produce an asymmetric E-cadherin-Bazooka complex to maintain segment boundaries. [PDF]
, 2013 Distributing junctional components around the cell periphery is key for epithelial tissue morphogenesis and homeostasis. We discovered that positioning of dynamic microtubules controls the asymmetric accumulation of E-cadherin.
Akhmanova +64 more
core +1 more source
PLoS ONE, 2012 The cadherin switch from E-cadherin to N-cadherin is considered as a hallmark of the epithelial-mesenchymal transition and progression of carcinomas. Although it enhances aggressive behaviors of adenocarcinoma cells, the significance and role of cadherin
Takashi Hashimoto +7 more
doaj +1 more source
Allosteric Regulation of E-Cadherin Adhesion [PDF]
Journal of Biological Chemistry, 2015 Cadherins are transmembrane adhesion proteins that maintain intercellular cohesion in all tissues, and their rapid regulation is essential for organized tissue remodeling. Despite some evidence that cadherin adhesion might be allosterically regulated, testing of this has been hindered by the difficulty of quantifying altered E-cadherin binding affinity
Nitesh, Shashikanth +8 more
openaire +2 more sources
Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-cadherin in vitro and in mice. [PDF]
, 2011 Previous studies have shown that decorin expression is significantly reduced in colorectal cancer tissues and cancer cells, and genetic deletion of the decorin gene is sufficient to cause intestinal tumor formation in mice, resulting from a ...
Bi, Xiuli +8 more
core +2 more sources
Zebrafish teeth as a model for repetitive epithelial morphogenesis: dynamics of E-cadherin expression [PDF]
, 2010 Background: The development of teeth is the result of interactions between competent mesenchyme and epithelium, both of which undergo extensive morphogenesis.
Verstraeten, Barbara +3 more
core +2 more sources
PLoS ONE, 2014 E-cadherin is a key cell-cell adhesion molecule but the impact of receptor density and the precise contribution of individual cadherin ectodomains in promoting cell adhesion are only incompletely understood.
Dagmar Fichtner +8 more
doaj +1 more source