Results 181 to 190 of about 13,602 (296)

Highly Potent Fluorogenic Ligands for Triplex DNA: 5‐Substituted 2‐(Naphthalen‐2‐yl)‐4H‐Chromen‐4‐Ones

Chemistry – A European Journal, EarlyView.
5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran, Landy Gu, Krege M. Christison, Kalee Thao, Liang Xue   +4 more
wiley   +1 more source

Development and pilot application of a point-of-need molecular xenomonitoring protocol for tsetse (Glossina sp.) in a low-resource setting. [PDF]

PLoS Negl Trop Dis
Saldanha I, Aziku E, Trima AT, Drapari V, Garrod G, Ombanya H, Tirados I, Betson M, Mugenyi A, Dunkley S, Torr SJ, Hope A, Cunningham LJ.   +12 more
europepmc   +1 more source

Substituent‐Controlled Ring Opening of 1‐Substituted Benzocyclobutenes: Electronic Structure and Diradical Character of Ortho‐Quinodimethane Intermediates

Chemistry – A European Journal, EarlyView.
Experimental and computational studies elucidate how the electronic nature of substituents controls the ring‐opening temperature and diradical character of 1‐substituted benzocyclobutenes, enabling the rational design of o‐quinodimethane‐based synthetic transformations.
Magali Dallegre, Imen Abid, Roselyne Rosas, Maxime Dousset, Gaëlle Chouraqui, Laurent Commeiras, Didier Siri, Didier Gigmes, Anthony Kermagoret   +8 more
wiley   +1 more source

Automated measurement of macular neovascularization lesion size in nAMD using AI segmentation. [PDF]

Graefes Arch Clin Exp Ophthalmol
Vahldiek A, Heine L, Vahldiek B, Schröter J, Wolf JN, Swora M, Reissberg L, Pauleikhoff L, Kleesiek J, Pauleikhoff D.   +9 more
europepmc   +1 more source

Mild N‑Arylation of Sulfoximines With (Hetero)aryl Chlorides Enabled by α‐Methylnaphthyl‐tBuBrettPhos Palladium Triflate

Chemistry – A European Journal, EarlyView.
A readily accessible, air‐ and moisture‐stable palladium precatalyst, [Pd(1‐MeNAP)(tBuBrettPhos)]OTf, enables the direct N‐arylation of NH‐sulfoximines with (hetero)aryl chlorides under exceptionally mild conditions ideal for late‐stage diversification of drug‐like scaffolds.
Sourav Manna, Mahima Pilania, Kumarjit Sen, Nikolaos V. Tzouras, Angelino Doppiu, Lukas J. Gooßen   +5 more
wiley   +1 more source

Mean Basal Esophagogastric Junction Pressure Is a Better High-resolution Manometry Predictor of Gastroesophageal Reflux Disease Than Esophagogastric Junction Contractile Integral. [PDF]

J Neurogastroenterol Motil
Vespa E, Barchi A, Fanizza J, Barà R, Fasulo E, Bencardino S, Bernardi F, Faggiani I, Danese S, Passaretti S.   +9 more
europepmc   +1 more source

A General Strategy for the Synthesis of Jerangolids Enabled by π‐allyl Stille Coupling

Chemistry – A European Journal, EarlyView.
A general strategy for the synthesis of jerangolids is established, featuring a late‐stage π‐allyl Stille coupling of two advanced, highly customizable building blocks to form the skipped diene core. The approach provides access to all naturally occurring jerangolids, including jerangolid H, whose configuration is confirmed by NMR analysis.
Janick Schug, Bernd Morgenstern, Johann Jauch   +2 more
wiley   +1 more source

Dynamic functional evaluation of the anti-reflux mechanism with simultaneous endoscopy and manometry as a provocative test. [PDF]

Endoscopy
Inoue H, Tanabe M, Abiko S, Yamamoto K, Owada K, Nishikawa Y, Seewald S.   +6 more
europepmc   +1 more source

Expedient Discovery of a Metallaphotoredox Cyanomethylation for Synthesizing α‐Aryl Nitriles

Chemistry – A European Journal, EarlyView.
A metallaphotoredox cyanomethylation reaction has been developed for the synthesis of valuable α‐aryl nitrile intermediates. The methodology was successfully applied to diverse medicinally‐relevant substrates, providing an expedient route to anti‐cancer Senexin compounds, while also removing the need for toxic cyanide reagents. The mechanism was probed
Gemma C. Cook, Blandine McKay, Craig Jamieson, Lee J. Edwards, Charlotte Harriman, Zackary S. Read, Simon T. Bate   +6 more
wiley   +1 more source

Interplay of Orbital Overlap and Exciton Coupling in the Optical Properties of Adamantylethynyl‐Substituted Pyrene Molecular Crystals

Chemistry – A European Journal, EarlyView.
Sterically shielded adamantylethynyl‐substituted pyrenes form quasi‐one‐dimensional π‐stacks that enable direct quantification of solution‐to‐crystal spectral shifts. The optical response is dominated by band dispersion arising from frontier crystal orbitals, while excitonic contributions are secondary.
Benedikt Herbert, Kazutaka Shoyama
wiley   +1 more source