Results 71 to 80 of about 2,873 (215)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

THE DEVELOPMENT OF PROJECT BASED LEARNING E-MODULE FOR THE SUBJECT OF COMPUTER GRAPHICS

Jurnal Pendidikan Teknologi dan Kejuruan, 2016
This study aims to (1) design e-learning module development as learning media for computer graphics subject at Department of Visual Communication Design for Grade 10 at SMK 1 Sukasada, (2) implement e-module design development as computer graphics ...
Luh Astiti, I Gede Mahendra Darmawiguna, Gede Saindra Santyadiputra   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Development Studies: E-Module Based on Ethnomathematics to Improve Problem-Solving Ability at Junior High School10 Metro

IndoMath
There are still many students who need help solving mathematical- problems. The need for attractive, easy-to-understand, and culture-based learning is essential for students.
Rahma Nur Lita, Juitaning Mustika
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Development of Flipbook-Based E-Module Teaching Materials to Enhance Independence and Learning Outcomes of High School Students

Jurnal Paedagogy
This study aims to develop a flipbook-based e-module as an innovative teaching material to enhance students’ independence and learning outcomes in economics at SMA Kalam Kudus Medan.
Erni Rugun Maria Pardede, Dede Ruslan, Arwansyah Arwansyah   +2 more
doaj   +1 more source

Penilaian E-Modul Grading Pola Celana

Practice of Fashion and Textile Education Journal
ABSTRAK Penelitian ini bertujuan untuk mengetahui hasil penilaian bahan ajar berupa E-Modul Grading Pola Celana. Penelitian yang digunakan adalah penelitian kuantitatif dengan metode penelitian pre-experimental dengan desain one-shot case study dengan teknik analisis data yang digunakan yaitu kuantitatif deskriptif.
Nafisah, Zahra, Eneng Lutfia, Prabawati, Melly   +2 more
openaire   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source