Results 81 to 90 of about 2,873 (215)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Jurnal Vokasi Dewantara (JVD)Abstrak: Penelitian dan pengembangan ini bertujuan untuk menghasilkan media pembelajaran berupa E-Modul Gambar Teknik berbasis Android yang layak digunakan untuk pembelajaran Gambar Teknik . penelitian ini merupakan jenis penelitian pengembangan R&D (research and development) dengan menggunakan tahapan 4-D.
Muhammad Rifqi anwar KHODIJAH +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Innovative Learning Using E-Modules
JETISH: Journal of Education Technology Information Social Sciences and HealthThis research discusses the innovative use of e-modules in learning and the challenges in creating or developing creative and innovative e-modules. Education in the current digital era is undergoing a significant revolution with the adoption of technology as the main catalyst for change.
Mahardika Ardi Manggala +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
The Flat Dimension of Mixed Abelian Groups as $E$-Modules
Rocky Mountain Journal of Mathematics, 1995 Let \(G\) be an abelian group and let \(E = E(G)\) denote its endomorphism ring. Then \(G\) is in a natural way a left \(E\)-module. It was R. S. Pierce who asked for a way to calculate the flat dimension \(fd_E(G)\) of the \(E\)-module \(_EG\). The present paper is devoted to this topic for the case that \(G\) belongs to a certain class \(\mathcal G\)
Albrecht, Ulrich F. +2 more
openaire +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source