Results 141 to 150 of about 20,409,847 (334)

Centralization of the System of E-Participation in the Russian Federation: Expert Interviews Data

Управленческое консультирование
This article presents the results of the study aimed at analyzing the institutional transformations of the E-Participation system in Russia. Since 2020, the e-participation system in Russia has undergone significant transformations associated with the ...
G. O. Panfilov, A. V. Chugunov
doaj   +1 more source

Online participation: the Woodberry Down experiment [PDF]

, 2002
The internet and world wide web are generating radical changes in the way we are able tocommunicate. Our ability to engage communities and individuals in designing theirenvironment is also beginning to change as new digital media provide ways in ...
Batty, M, Batty, S, Evans, S, Hudson-Smith, A   +3 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

How Do Researchers and Public Officials Co-Navigate e-Participation Implementation? An Action-Research Experience with South African Municipalities

Systems
How can local governments in the Global South effectively implement and sustain digital public participation initiatives, and what specific roles do public officials and knowledge intermediaries play in catalysing and supporting this digital ...
Odilile Ayodele, Paul Plantinga, Diana Sanchez-Bentacourt, Simangele Dlamini, Nonkululeko Dlamini   +4 more
doaj   +1 more source

E-Participation for the Net-Zero Transition: Designing for Youth Engagement in E-Participation Systems

, 2023
Klimaendringene har stadig mer omfattende globale konsekvenser, og det kreves umiddelbar handling for å oppnå målene fastsatt i Parisavtalen. For å begrense global oppvarming til 1,5 °C, må utslippene reduseres med 45% innen 2030 og nå netto null innen 2050.
Slorer, Isabel Sørheim, Hansen, Benedicte Kaltoft   +1 more
openaire   +2 more sources

Limitations of the e-Participation

Central and Eastern European eDem and eGov Days, 2018
e-Participation was considered to be proper solution for the long term decline of political participation at different levels. However, recent events show that there is very limited space for the political participation, which is considered to be functional. The paper explores the changes in citizens' participation after the introduction of different e-
openaire   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Factors affecting e-government adoption in the state of Qatar [PDF]

, 2010
Electronic government (e-government) initiatives are in their early stages in many developing countries and faced with various issues pertaining to their implementation, adoption and diffusion.
Al-Shafi, S, Weerakkody, V
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source