Results 151 to 160 of about 21,181,337 (333)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
REGIONAL DATA AND KNOWLEDGE MANAGEMENT FOR THE DESIGN OF NEW E-GOVERNMENT SERVICES [PDF]
The paper introduces an innovative approach related to the sustainable regional strategy design and implementation, suggesting the process re-engineering according to the new knowledge management and citizen-oriented governance paradigm.
Mihaela MUREªAN
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Evaluating the transition of e-Government: A review of local authorities in England [PDF]
, 2009 The goal of e-Government is seen as a panacea for governmental authorities. The emerging needs of citizens, their inclusion and engagement in policy development, political and participatory processes have meant new perspectives on e-Government are ...
Sharif, A M, Tassabehji, R, Wilkinson, J
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
المشاركة الإلكترونية – نحو مفهوم يتجاوز التغريد-
مجلة الآداب و العلوم الإجتماعية, 2018 تسعى الورقة البحثية إلى مناقشة مدى مساهمة أدوات المشاركة القائمة على تكنولوجيا المعلومات والاتصالات بشكل مباشر في تحقيق نتائج المشاركة الإلكترونية. مفترضة بأن توفير المعلومات وتيسير الإجراءات تعزز قدرة وفعالية المواطنين في المشاركة في تسيير الشأن العام ...
يوسف زدام
doaj
Digitalization of public consultations in rural municipalities of the Wielkopolskie Voivodship
Rozwój Regionalny i Polityka RegionalnaThe development of e-participation and e-consultations is particularly characteristic of large cities, which is why researchers tend to focus on larger urban areas. This article adopts a different perspective.
Piotr Glenc
doaj +1 more source
Proceedings of the 15th International Conference on Theory and Practice of Electronic Governance, 2022 Leif Sundberg, Katarina Gidlund
openaire +1 more source
Doing IT for Themselves: Management versus Autonomy in Youth E-Citizenship [PDF]
, 2008 Part of the Volume on Civic Life Online: Learning How Digital Media Can Engage Youth. This chapter explores tensions between managed and autonomous conceptions of youth e-citizenship as manifested in six UK-based projects.
Stephen Coleman
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source