Results 201 to 210 of about 22,586,567 (311)

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Parental motivations, facilitators, and barriers to participating in a pediatric vaccine trial in Kathmandu, Nepal: A qualitative study. [PDF]

Hum Vaccin Immunother
Firth C, Das NK, Khatri E, Bijukchhe S, Chuke S, Curtis B, Gurung M, Kelly S, O'Mahony E, Pollard AJ, Sharma AK, Shrestha S, Vanderslott S, Adhikari B.   +13 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Reply: Generative AI-Powered Virtual Assistant for Guideline-Directed Medical Therapy Optimization. [PDF]

JACC Adv
Navarese EP, Leader JH, Koolaji S, Kereiakes DJ, Gorog DA.   +4 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Trust and other instruments of asset segregation for inheritance purposes

reservedL'elaborato si occupa di esaminare i tratti essenziali dell'istituto del trust nell'esperienza giuridica italiana, cd. trust interno, con particolare attenzione alla figura del trust stipulato inter vivos con efficacia post mortem, quale ...
DE CHECCHI, ALESSANDRO
core  

Public participation, institutional trust, and distributive justice in wind and solar projects. [PDF]

Environ Manage
Miguel T, Robaina M, Botelho A, Lima F, Ramalho E, Madaleno M.   +5 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Correction to: Hybrid B- and T-Cell Immunity Associates With Protection Against Breakthrough Infection After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Avon Longitudinal Study of Parents and Children (ALSPAC) Participants. [PDF]

J Infect Dis
europepmc   +1 more source

Patient-Clinician Trust Is Independent of General Interpersonal Trust Among People Seeking Musculoskeletal Specialty Care. [PDF]

J Patient Exp
Jaarsma E, Ahlfinger Z, Azib N, Razi A, Wickman J, Ring D, Brinkman N.   +6 more
europepmc   +1 more source